Sleep is a vital function of the nervous system that contributes to brain and bodily
homeostasis, energy levels, cognitive ability, and other key functions of a variety of …

The cannabinoid receptor family currently includes twotypes: CB 1, characterized in
neuronal cells and brain, and CB 2, characterized in immune cells and tissues. CB 1 and CB …

Cognitive impairment is one of the most important negative consequences associated with
cannabis consumption. We found that CB1 cannabinoid receptor (CB1R) activation …

After their discovery, the two known cannabinoid receptors, CB1 and CB2, have been the
focus of research into the cellular signalling mechanisms of cannabinoids. The initial …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in …

Abstract Delta9‐tetrahydrocannabinol (THC), the main psychoactive component in
Cannabis sativa preparations, exerts its central effects mainly through the G‐protein coupled …

With advances in basic and clinical neuroscience, many gaps have appeared in the
traditional monoamine theory of depression that have led to reformulation of the hypotheses …

Addiction involves alterations in multiple brain regions that are associated with functions
such as memory, motivation and executive control. Indeed, it is now well accepted that …

Molecular mechanisms regulating the development of physiological and behavioral
tolerance to cannabinoids are not well understood. Two cellular correlates implicated in the …