Bacteria possess a repertoire of versatile protein kinases modulating diverse aspects of their
physiology by phosphorylating proteins on various amino acids including histidine, cysteine …

Signal transduction is an essential activity of all living cells. Broadly defined, signal
transduction is the sensing of a signal or input and its conversion into an output or response …

Strategies for expanding the sensor space of designer receptors are urgently needed to
tailor cell-based therapies to respond to any type of medically relevant molecules. Here, we …

Prokaryotic cell wall biosynthesis is coordinated with cell growth and division, but the
mechanisms regulating this dynamic process remain obscure. Here, we describe a …

The Mycobacterium tuberculosis protein kinase B (PknB) comprises an intracellular kinase
domain, connected through a transmembrane domain to an extracellular region that …

Protein phosphorylation on serine, threonine and tyrosine is recognized as a major tool of
signal transduction in bacteria. However, progress in the field has been hampered by the …

All domains of life utilize protein phosphorylation as a mechanism of signal transduction. In
bacteria, protein phosphorylation was classically thought to be mediated exclusively by …

Enterococcus faecalis is a Gram-positive bacterium that is a major cause of hospital-
acquired infections due, in part, to its intrinsic resistance to cell wall-active antimicrobials …

Abstract The Mycobacterium tuberculosis kinase PknB is essential for growth and survival of
the pathogen in vitro and in vivo. Here we report the results of our efforts to elucidate the …

Many Gram-positive bacteria coordinate cellular processes by signaling through Ser/Thr
protein kinases (STPKs), but the architecture of these phosphosignaling cascades is …