TGF-β/BMP signaling and other molecular events: regulation of osteoblastogenesis and bone formation
Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …
fundamental role in the regulation of bone organogenesis through the activation of receptor …
[HTML][HTML] Gap junctions
Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …
Optimized BMSC-derived osteoinductive exosomes immobilized in hierarchical scaffold via lyophilization for bone repair through Bmpr2/Acvr2b competitive receptor …
A Liu, D Lin, H Zhao, L Chen, B Cai, K Lin, SGF Shen - Biomaterials, 2021 - Elsevier
Mesenchymal stem cell-derived exosomes (MSC-exos), with its inherent capacity to
modulate cellular behavior, are emerging as a novel cell-free therapy for bone regeneration …
modulate cellular behavior, are emerging as a novel cell-free therapy for bone regeneration …
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation
Emerging evidence indicates that osteoclasts direct osteoblastic bone formation. MicroRNAs
(miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However …
(miRNAs) have a crucial role in regulating osteoclast and osteoblast function. However …
Cancer-secreted hsa-miR-940 induces an osteoblastic phenotype in the bone metastatic microenvironment via targeting ARHGAP1 and FAM134A
K Hashimoto, H Ochi, S Sunamura… - Proceedings of the …, 2018 - National Acad Sciences
Bone metastatic lesions are classified as osteoblastic or osteolytic lesions. Prostate and
breast cancer patients frequently exhibit osteoblastic-type and osteolytic-type bone …
breast cancer patients frequently exhibit osteoblastic-type and osteolytic-type bone …
miR-214 targets ATF4 to inhibit bone formation
Emerging evidence indicates that microRNAs (miRNAs) have important roles in regulating
osteogenic differentiation and bone formation. Thus far, no study has established the …
osteogenic differentiation and bone formation. Thus far, no study has established the …
Sema3A regulates bone-mass accrual through sensory innervations
T Fukuda, S Takeda, R Xu, H Ochi, S Sunamura, T Sato… - Nature, 2013 - nature.com
Abstract Semaphorin 3A (Sema3A) is a diffusible axonal chemorepellent that has an
important role in axon guidance,,,,. Previous studies have demonstrated that Sema3a …
important role in axon guidance,,,,. Previous studies have demonstrated that Sema3a …
MicroRNA-138 regulates osteogenic differentiation of human stromal (mesenchymal) stem cells in vivo
T Eskildsen, H Taipaleenmäki… - Proceedings of the …, 2011 - National Acad Sciences
Elucidating the molecular mechanisms that regulate human stromal (mesenchymal) stem
cell (hMSC) differentiation into osteogenic lineage is important for the development of …
cell (hMSC) differentiation into osteogenic lineage is important for the development of …
A program of microRNAs controls osteogenic lineage progression by targeting transcription factor Runx2
Lineage progression in osteoblasts and chondrocytes is stringently controlled by the cell-
fate–determining transcription factor Runx2. In this study, we directly addressed whether …
fate–determining transcription factor Runx2. In this study, we directly addressed whether …
MicroRNA control of bone formation and homeostasis
JB Lian, GS Stein, AJ Van Wijnen, JL Stein… - Nature Reviews …, 2012 - nature.com
MicroRNAs (miRNAs) repress cellular protein levels to provide a sophisticated parameter of
gene regulation that coordinates a broad spectrum of biological processes. Bone …
gene regulation that coordinates a broad spectrum of biological processes. Bone …