Clinical translation of nanomedicines: Challenges, opportunities, and keys

MA Younis, HM Tawfeek, AAH Abdellatif… - Advanced drug delivery …, 2022 - Elsevier
Despite the massive interest and recent developments in the field of nanomedicine, only a
limited number of formulations have found their way to the clinics. This shortcoming reveals …

Strategies and progresses for enhancing targeted antibiotic delivery

A Nazli, DL He, D Liao, MZI Khan, C Huang… - Advanced drug delivery …, 2022 - Elsevier
Antibiotic resistance is a global health issue and a potential risk for society. Antibiotics
administered through conventional formulations are devoid of targeting effect and often …

Acid-sensitive prodrugs; a promising approach for site-specific and targeted drug release

A Nazli, MZI Khan, Á Rácz, S Béni - European Journal of Medicinal …, 2024 - Elsevier
Drugs administered through conventional formulations are devoid of targeting and often
spread to various undesired sites, leading to sub-lethal concentrations at the site of action …

A review on carbon nanotubes family of nanomaterials and their health field

CL Brito, JV Silva, RV Gonzaga, MA La-Scalea… - ACS …, 2024 - ACS Publications
The use of carbon nanotubes (CNTs), which are nanometric materials, in pathogen
detection, protection of environments, food safety, and in the diagnosis and treatment of …

Biocatalytic insights for the synthesis of new potential prodrugs: design of two ibuprofen derivatives

F Zappaterra, F Presini, V Venturi, LA Lerin… - Applied Sciences, 2023 - mdpi.com
Due to its effectiveness, ibuprofen is one of the most popular anti-inflammatory drugs
worldwide. However, the poor water solubility of this active ingredient severely limits its …

Prodrugs: Harnessing chemical modifications for improved therapeutics

R Kumar, C Kaur, K Kaur, N Khurana… - Journal of Drug Delivery …, 2023 - Elsevier
A drug is a chemical substance which possesses medicinal properties and exerts
pharmacological action upon administration into the body. When a drug gets metabolized …

Profiling tear film enzymes reveals major metabolic pathways involved in the homeostasis of the ocular surface

M Akkurt Arslan, F Brignole-Baudouin, S Chardonnet… - Scientific Reports, 2023 - nature.com
The ocular surface (OS) enzymes are of great interest due to their potential for novel ocular
drug development. We aimed first to profile and classify the enzymes of the OS to describe …

A New Process for the Synthesis of Budesonide 21-Phosphate and Evaluation in a Murine Model of Inflammation

A Corvino, E Granato, A Scognamiglio, F Fiorino… - …, 2024 - pmc.ncbi.nlm.nih.gov
In this study, a new and straightforward process for the preparation of budesonide 21-
phosphate (Bud-21P) and its disodium salt (Bud-21P-Na2) is described. The method results …

[HTML][HTML] Exploring Ester Prodrugs: A Comprehensive Review of Approaches, Applications, and Methods

G Zhou - Pharmacology & Pharmacy, 2024 - scirp.org
The review provides an overview of the approaches, applications, and methods for ester
prodrugs. Ester prodrugs are pharmacologically inactive compounds in their original form …

Inhalable Prodrugs for Pulmonary Therapeutics

PP Mehta, V Dhapte-Pawar - Pulmonary Drug Delivery Systems: Material …, 2023 - Springer
Like the liver's major metabolic organ, pulmonary airways contain many potential
metabolizing enzymes and metabolic pathways. Notably, the pulmonary metabolic network …