Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

The beneficial actions of nonsteroidal anti‐inflammatory drugs (NSAIDs) have been linked to
their ability to inhibit inducible COX‐2 at sites of inflammation, and their side effects (eg …

Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique
nonallergic reactions, consisting of attacks of rhinitis and asthma. These hypersensitivity …

Angioedema without urticaria is a clinical syndrome characterised by self-limiting local
swellings involving the deeper cutaneous and mucosa tissue layers. Most occurrences of …

Background: Subjects with aspirin-intolerant asthma (AIA) respond with bronchoconstriction
and extrapulmonary adverse reactions to conventional nonsteroidal anti-inflammatory drugs …

BACKGROUND: The safety of new anti-inflammatory drugs in patients intolerant to classic
cyclooxygenase (COX) inhibitors with urticaria and angioedema has not been determined …

Abstract NSAIDs—including aspirin (ASA)—that inhibit cyclooxygenase (COX)-1 induce
nonallergic hypersensitivity reactions consisting of attacks of rhinitis and asthma. Such …

Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in urticaria and
angioedema, is being observed with increasing frequency. Prevalence rates range from 0.1 …

Acknowledging urticaria as a symptom of mast cell degranulation is stressed. The biology of
the mast cell, and the recognized immunologic and non-immunologic mast cell …

Cyclooxygenases and their metabolites are important regulators of inflammatory responses
and play critical roles in regulating the differentiation of T helper cell subsets in inflammatory …