The process of aging results in a host of changes at the cellular and molecular levels, which
include senescence, telomere shortening, and changes in gene expression. Epigenetic …

Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Most disease-associated genetic variants are noncoding, making it challenging to design
experiments to understand their functional consequences,. Identification of expression …

The aryl hydrocarbon receptor (AHR) is a nuclear receptor that modulates the response to
environmental stimuli. It was recognized historically for its role in toxicology but, in recent …

Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …

Biomarkers are naturally-occurring characteristics by which a particular pathological process
or disease can be identified or monitored. They can reflect past environmental exposures …

Several studies have recently identified strong epigenetic signals related to tobacco
smoking. However, an aspect that did not receive much attention is the evolution of …

There are persistent socioeconomic disparities in many aspects of child development in
America. Relative to their affluent peers, children of low socioeconomic status (SES) …

DNA hypomethylation in certain genes is associated with tobacco exposure but it is
unknown whether these methylation changes translate into increased lung cancer risk. In an …