Deregulation of protein tyrosine kinase (PTK) activity is implicated in various proliferative
conditions. Multi-target tyrosine kinase inhibitors (TKIs) are increasingly used for the …

Renal cell carcinoma (RCC) comprises 2‑3% of all malignant tumors in adults. Many studies
have established the key roles of smoking, hypertension and other components of metabolic …

Introduction: Type 2 diabetes is characterized by hyperglycemia that is the result of β-cell
failure in the setting of peripheral insulin resistance. It is estimated that greater than 300 …

Cervical cancer is one of the most prevalent forms of cancer occurring across the world and
it has been observed that about 99.7% of cervical cancer cases occur due to infections with …

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease caused by proinflammatory
T cell infiltration associated cytokine secretion and reactive oxygen species (ROS) …

Tyrosine kinase inhibitors (TKIs) have been studied extensively in cancer research,
ultimately resulting in the approval of many drugs for cancer therapy. Recent evidence from …

Background Diabetes mellitus (DM) is a group of metabolic disorders that have an increased
risk of macro and micro-vascular complications due to lipid dysfunction. The present drug …

Background Diabetes reduces the activity of CYP3A4 and may increase the exposure for the
drugs metabolized by the isoenzyme. Sorafenib is a multi-targeted tyrosine kinase inhibitor …

According to clinical data, some tyrosine kinase inhibitors (TKIs) possess antidiabetic effects.
Several proposed mechanisms were assigned to them, however their mode of action is not …

Background Diabetes mellitus (DM) is a complex metabolic disorder which affects the
function of numerous tissues and alters the pharmacokinetic parameters of many drugs. As …