Metabolism and ATP levels within the oocyte and adjacent cumulus cells are associated
with quality of oocyte and optimal development of a healthy embryo. Lipid metabolism …

For successful mitosis, Cyclin B1 and Securin must be degraded efficiently before
anaphase. Destruction of these mitotic regulators by the 26S proteasome is the result of their …

Abstract Liver receptor homolog-1 (LRH1) has been shown to promote tumor proliferation
and development. However, the functions of LRH1 in mediating cancer cells …

The DNA damage response (DDR) is comprised of a network of proteins that respond to
DNA damage. Mediator of DNA Damage Checkpoint 1 (MDC1) plays an early and important …

Abstract The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase,
facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining …

The chromatin structure is important for recognition and repair of DNA damage. Many DNA
damage response proteins accumulate in large chromatin domains flanking sites of DNA …

The origins of giraffe's imposing stature and associated cardiovascular adaptations are
unknown. Okapi, which lacks these unique features, is giraffe's closest relative and provides …

The anaphase-promoting complex/cyclosome (APC/C), an essential ubiquitin protein ligase,
regulates mitotic progression and exit by enhancing degradation of cell cycle regulatory …

Antiprogestins constitute a group of compounds, developed since the early 1980s, that bind
progesterone receptors with different affinities. The first clinical uses for antiprogestins were …

The DNA damage response mediators, 53BP1 and MDC1, play a central role in checkpoint
activation and DNA repair. Here we establish that human 53BP1 and MDC1 interact directly …