The genetics of sleep apnea

S Redline, PV Tishler - Sleep medicine reviews, 2000 - Elsevier
Obstructive sleep apnea hypopnea syndrome (OSAHS) is a complex chronic condition that
is undoubtedly influenced by multiple factors. Accumulating data suggest that there are …

Mouse phenotyping

H Fuchs, V Gailus-Durner, T Adler, JA Aguilar-Pimentel… - Methods, 2011 - Elsevier
Model organisms like the mouse are important tools to learn more about gene function in
man. Within the last 20years many mutant mouse lines have been generated by different …

High tidal volume upregulates intrapulmonary cytokines in an in vivo mouse model of ventilator-induced lung injury

MR Wilson, S Choudhury… - Journal of Applied …, 2003 - journals.physiology.org
Mechanical ventilation has been demonstrated to exacerbate lung injury, and a sufficiently
high tidal volume can induce injury in otherwise healthy lungs. However, it remains …

Selected contribution: phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia

DD Fuller, AG Zabka, TL Baker… - Journal of applied …, 2001 - journals.physiology.org
Episodic hypoxia evokes a sustained augmentation of respiratory motor output known as
long-term facilitation (LTF). Phrenic LTF is prevented by pretreatment with the 5 …

Unrestrained plethysmography is an unreliable measure of airway responsiveness in BALB/c and C57BL/6 mice

A Adler, G Cieslewicz, CG Irvin - Journal of applied …, 2004 - journals.physiology.org
There has been significant utilization of the technique described by Hamelmann et al.(Am J
Respir Crit Care Med 156: 766–775, 1997) in which a parameter, enhanced pause (Penh) …

Obstructive sleep apnea syndrome: from phenotype to genetic basis

M Casale, M Pappacena, V Rinaldi, F Bressi… - Current …, 2009 - ingentaconnect.com
Obstructive sleep apnea syndrome (OSAS) is a complex chronic clinical syndrome,
characterized by snoring, periodic apnea, hypoxemia during sleep, and daytime …

Meta-analysis of some physiologic, metabolic and oxidative responses of sheep exposed to environmental heat stress

IB Slimen, M Chniter, T Najar, A Ghram - Livestock Science, 2019 - Elsevier
A meta-analysis was performed from 66 references retained from a total of 147 ones. The
aim was to study the relationship between the THI and some physiologic, metabolic and …

Differential effects of mechanical ventilatory strategy on lung injury and systemic organ inflammation in mice

OU Gurkan, C O'Donnell, R Brower… - … of Physiology-Lung …, 2003 - journals.physiology.org
Patients with acute respiratory distress syndrome are at increased risk for developing
multiorgan system dysfunction. The goal of this study was to establish an in vivo murine …

Pulmonary function assessment by whole-body plethysmography in restrained versus unrestrained mice

MP DeLorme, OR Moss - Journal of pharmacological and toxicological …, 2002 - Elsevier
Introduction: The evaluation of pulmonary physiological measurements in laboratory
animals is an essential tool in many biomedical and toxicological research areas. Recently …

Production of amphiregulin and recovery from influenza is greater in males than females

MS Vermillion, RL Ursin, DIT Kuok… - Biology of sex …, 2018 - Springer
Background Amphiregulin (AREG) is an epidermal growth factor that is a significant
mediator of tissue repair at mucosal sites, including in the lungs during influenza A virus …