15 years of GWAS discovery: realizing the promise
It has been 15 years since the advent of the genome-wide association study (GWAS) era.
Here, we review how this experimental design has realized its promise by facilitating an …
Here, we review how this experimental design has realized its promise by facilitating an …
The inheritance of social status: England, 1600 to 2022
G Clark - Proceedings of the National Academy of Sciences, 2023 - National Acad Sciences
A lineage of 422,374 English people (1600 to 2022) contains correlations in social
outcomes among relatives as distant as 4th cousins. These correlations show striking …
outcomes among relatives as distant as 4th cousins. These correlations show striking …
Artificial intelligence for dementia genetics and omics
Genetics and omics studies of Alzheimer's disease and other dementia subtypes enhance
our understanding of underlying mechanisms and pathways that can be targeted. We …
our understanding of underlying mechanisms and pathways that can be targeted. We …
Social and genetic associations with educational performance in a Scandinavian welfare state
MA Isungset, D Conley… - Proceedings of the …, 2022 - National Acad Sciences
Recent research has suggested that across Western developed societies, the influence of
genetics on educational outcomes is relatively constant. However, the degree to which …
genetics on educational outcomes is relatively constant. However, the degree to which …
The Norwegian Mother, Father, and Child cohort study (MoBa) genotyping data resource: MoBaPsychGen pipeline v. 1
Abstract Background The Norwegian Mother, Father, and Child Cohort Study (MoBa) is a
population-based pregnancy cohort, which includes approximately 114,500 children, 95,200 …
population-based pregnancy cohort, which includes approximately 114,500 children, 95,200 …
Assortative mating and parental genetic relatedness contribute to the pathogenicity of variably expressive variants
We examined more than 97,000 families from four neurodevelopmental disease cohorts and
the UK Biobank to identify phenotypic and genetic patterns in parents contributing to …
the UK Biobank to identify phenotypic and genetic patterns in parents contributing to …
The heritability and persistence of social class in England
JJ Lee - Proceedings of the National Academy of Sciences, 2023 - National Acad Sciences
The extent to which hereditary abilities affect social class has been a matter of interest since
classical times (1). In 1918, Ronald Fisher published a framework for answering such …
classical times (1). In 1918, Ronald Fisher published a framework for answering such …
The structure of psychiatric comorbidity without selection and assortative mating
The widespread comorbidity observed across psychiatric disorders may be the result of
processes such as assortative mating, gene-environment correlation, or selection into …
processes such as assortative mating, gene-environment correlation, or selection into …
Conventional twin studies overestimate the environmental differences between families relevant to educational attainment
Estimates of shared environmental influence on educational attainment (EA) using the
Classical Twin Design (CTD) have been enlisted as genetically sensitive measures of …
Classical Twin Design (CTD) have been enlisted as genetically sensitive measures of …
Disentangling direct and indirect genetic effects from partners and offspring on maternal depression using trio-GCTA
Maternal depressive symptoms are highly prevalent and can negatively impact affected
individuals and family members. Understanding etiological influences on maternal …
individuals and family members. Understanding etiological influences on maternal …