Monitoring and modulating the diversity of signals used by neurons and glia in a closed-loop
fashion is necessary to establish causative links between biochemical processes within the …

The ability to simultaneously image the spatiotemporal activity signatures from many
neurons during unrestrained vertebrate behaviors has become possible through the …

Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer.
Nevertheless, AAVs that provide efficient transduction across specific organs or cell …

Video-based screening of pooled libraries is a powerful approach for directed evolution of
biosensors because it enables selection along multiple dimensions simultaneously from …

INTRODUCTION Sleep homeostasis, the balance between the duration of sleep and
wakefulness, is a fundamental feature of the sleep-wake cycle. During wakefulness, sleep …

Genetically encoded indicators engineered from G-protein-coupled receptors are important
tools that enable high-resolution in vivo neuromodulator imaging. Here, we introduce a …

A central goal in neuroscience is to determine how the brain's neuronal circuits generate
perception, cognition and emotions and how these lead to appropriate behavioural actions …

The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …

Animal behavior originates from neuronal activity distributed across brain-wide networks.
However, techniques available to assess large-scale neural dynamics in behaving animals …

Fiber photometry is a key technique for characterizing brain-behavior relationships in vivo.
Initially, it was primarily used to report calcium dynamics as a proxy for neural activity via …