For decades, immunologists have studied the role of circulating immune cells in host
protection, with a more recent appreciation of immune cells resident within the tissue …

Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and
play crucial roles in both the promotion of immune defense and the maintenance of immune …

The innate immune system is critical for inducing durable and protective T cell responses to
infection and has been increasingly recognized as a target for cancer immunotherapy. In this …

Neuroinflammatory diseases, such as multiple sclerosis, are characterized by invasion of the
brain by autoreactive T cells. The mechanism for how T cells acquire their encephalitogenic …

The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that
signal through cell surface G protein‐coupled heptahelical chemokine receptors. They are …

The liver connects the intestinal portal vasculature with the general circulation, using a
diverse array of immune cells to protect from pathogens that translocate from the gut. In liver …

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to
distant sites within the body, ultimately reducing the survival of patients with cancer. To …

Cell migration is an adaptive process that depends on and responds to physical and
molecular triggers. Moving cells sense and respond to tissue mechanics and induce …

The lymphatic system, composed of initial and collecting lymphatic vessels as well as lymph
nodes that are present in almost every tissue of the human body, acts as an essential …

The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue,
which has the holistic function to maintain the local physiologic environment for every cell in …