Arthropod-borne viruses (arboviruses) are an important threat to human and animal health
globally. Among these, zoonotic diseases account for billions of cases of human illness and …

One of the major goals in immunology research is to understand the regulatory mechanisms
that underpin the rapid switch on/off of robust and efficient effector (Teffs) or regulatory …

HIV-1 post-integration latency in CD4+ lymphocytes is responsible for viral persistence
despite treatment, but mechanisms involved in the establishment of latent viral reservoirs are …

Massive activation of infected CD4+ T cells during acute HIV-1 infection leads to reservoir
seeding and T-cell destruction. During T-cell activation, the antiviral effect of the innate factor …

A potential strategy to cure HIV-1 infection is to use latency reversing agents (LRAs) to
eliminate latent reservoirs established in resting CD4+ T (rCD4+) cells. As no drug has been …

Background The BCN02-trial combined therapeutic vaccination with a viral latency reversing
agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored …

Macrocyclic diterpenoids produced by plants of the Euphorbiaceae family are of
considerable interest due to their high structural diversity; and their therapeutically relevant …

Targeting cellular proteins with antibodies, to better understand cellular signaling pathways
in the context of disease modulation, is a fast-growing area of investigation. Humanized …

The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II
elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the …

We have shown previously that prostratin, a non-tumor promoting phorbol ester, inhibits
chikungunya virus (CHIKV)-induced cytopathic effects in vitro. Prostratin is a potent activator …