Endocannabinoids were implicated in a variety of pathological conditions including anxiety
and are considered promising new targets for anxiolytic drug development. The optimism …

Early life stress (ELS) increases predisposition to depression. We compared the effects of
treatment with the fatty acid amide hydrolase (FAAH) inhibitor URB597, and the selective …

The pathophysiology of major depressive disorder (MDD) is diverse and multi-factorial, yet
treatment strategies remain limited. While women are twice as likely to develop the disorder …

Cannabidiol (CBD) is a potential antidepressant agent. We examined the association
between the antidepressant effects of CBD and alterations in brain microRNAs in the …

Post-Traumatic Stress Disorder (PTSD) is a chronic mental disorder characterized by
symptoms of panic and anxiety, depression, impaired cognitive functioning, and difficulty in …

A disintegrin and metalloproteinase 10 (ADAM10) plays an essential role in the regulation of
survival, proliferation, migration, and differentiation of various neural cells. Nevertheless, the …

Post-traumatic stress disorder (PTSD) involves dysregulation of stress modulators,
particularly corticotrophin-releasing factor (CRF) and glucocorticoid receptor …

Background Post-traumatic stress disorder (PTSD) is a debilitating disorder that results from
exposure to various traumatic events. Endocannabinoids levels change during PTSD …

The number of patients reporting the use of cannabis for medical purposes, whether through
state-regulated medical marijuana programs or through over-the-counter hemp extracts …