Electrochemical late-stage functionalization
Late-stage functionalization (LSF) constitutes a powerful strategy for the assembly or
diversification of novel molecular entities with improved physicochemical or biological …
diversification of novel molecular entities with improved physicochemical or biological …
Direct photocatalyzed hydrogen atom transfer (HAT) for aliphatic C–H bonds elaboration
Direct photocatalyzed hydrogen atom transfer (d-HAT) can be considered a method of
choice for the elaboration of aliphatic C–H bonds. In this manifold, a photocatalyst (PCHAT) …
choice for the elaboration of aliphatic C–H bonds. In this manifold, a photocatalyst (PCHAT) …
Late-stage C–H functionalization offers new opportunities in drug discovery
L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
Late-stage functionalization for improving drug-like molecular properties
NJ Castellino, AP Montgomery, JJ Danon… - Chemical …, 2023 - ACS Publications
The development of late-stage functionalization (LSF) methodologies, particularly C–H
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
functionalization, has revolutionized the field of organic synthesis. Over the past decade …
Photocatalysis in the life science industry
L Candish, KD Collins, GC Cook, JJ Douglas… - Chemical …, 2021 - ACS Publications
In the pursuit of new pharmaceuticals and agrochemicals, chemists in the life science
industry require access to mild and robust synthetic methodologies to systematically modify …
industry require access to mild and robust synthetic methodologies to systematically modify …
Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds
R Cannalire, S Pelliccia, L Sancineto… - Chemical Society …, 2021 - pubs.rsc.org
The late stage functionalization (LSF) of complex biorelevant compounds is a powerful tool
to speed up the identification of structure–activity relationships (SARs) and to optimize …
to speed up the identification of structure–activity relationships (SARs) and to optimize …
Carbon–Carbon Bond Cleavage for Late-Stage Functionalization
YF Liang, M Bilal, LY Tang, TZ Wang, YQ Guan… - Chemical …, 2023 - ACS Publications
Late-stage functionalization (LSF) introduces functional group or structural modification at
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …
the final stage of the synthesis of natural products, drugs, and complex compounds. It is …
Late-stage functionalization
J Börgel, T Ritter - Chem, 2020 - cell.com
The term late-stage functionalization (LSF) is recent but is now frequently used in the field of
organic methodology development to describe transformations on complex molecules. Such …
organic methodology development to describe transformations on complex molecules. Such …
Nickel-catalyzed hydrogenative coupling of nitriles and amines for general amine synthesis
VG Chandrashekhar, W Baumann, M Beller… - Science, 2022 - science.org
Efficient and general methods for the synthesis of amines remain in high demand in the
chemical industry. Among the many known processes, catalytic hydrogenation is a cost …
chemical industry. Among the many known processes, catalytic hydrogenation is a cost …
Green chemistry meets medicinal chemistry: a perspective on modern metal-free late-stage functionalization reactions
The progress of drug discovery and development is paced by milestones reached in organic
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …
synthesis. In the last decade, the advent of late-stage functionalization (LSF) reactions has …