Microglial phagocytosis: a disease-associated process emerging from Alzheimer's disease genetics
Alzheimer's disease (AD) is a debilitating, chronic neurodegenerative disease. Genetic
studies involving genome-wide association studies (GWAS) and meta-analysis have …
studies involving genome-wide association studies (GWAS) and meta-analysis have …
Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia
M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …
cure for it. Several pathologic alterations have been described in the brain of AD patients …
Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain
J Marschallinger, T Iram, M Zardeneta, SE Lee… - Nature …, 2020 - nature.com
Microglia become progressively activated and seemingly dysfunctional with age, and
genetic studies have linked these cells to the pathogenesis of a growing number of …
genetic studies have linked these cells to the pathogenesis of a growing number of …
Neuronal γ-secretase regulates lipid metabolism, linking cholesterol to synaptic dysfunction in Alzheimer's disease
S Essayan-Perez, TC Südhof - Neuron, 2023 - cell.com
Presenilin mutations that alter γ-secretase activity cause familial Alzheimer's disease (AD),
whereas ApoE4, an apolipoprotein for cholesterol transport, predisposes to sporadic AD …
whereas ApoE4, an apolipoprotein for cholesterol transport, predisposes to sporadic AD …
Long-term running exercise improves cognitive function and promotes microglial glucose metabolism and morphological plasticity in the hippocampus of APP/PS1 …
S Zhang, L Zhu, Y Peng, L Zhang, F Chao… - Journal of …, 2022 - Springer
Background The role of physical exercise in the prevention of Alzheimer's disease (AD) has
been widely studied. Microglia play an important role in AD. Triggering receptor expressed …
been widely studied. Microglia play an important role in AD. Triggering receptor expressed …
Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer's disease: from current to future challenges
Increasing life expectancy has led to an aging population, which has consequently
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …
increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of …
Neuroinflammation as a potential therapeutic target in Alzheimer's disease
P Liu, Y Wang, Y Sun, G Peng - Clinical Interventions in Aging, 2022 - Taylor & Francis
Although amyloid-β (Aβ) peptide accumulation is considered as a key early event in the
pathogenesis of Alzheimer's disease (AD), the precise pathophysiology of this deadly illness …
pathogenesis of Alzheimer's disease (AD), the precise pathophysiology of this deadly illness …
Hypoxia compromises the mitochondrial metabolism of Alzheimer's disease microglia via HIF1
R March-Diaz, N Lara-Ureña, C Romero-Molina… - Nature Aging, 2021 - nature.com
Genetic Alzheimer's disease (AD) risk factors associate with reduced defensive amyloid β
plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to …
plaque-associated microglia (AβAM), but the contribution of modifiable AD risk factors to …
Molecular hydrogen attenuates sepsis-induced neuroinflammation through regulation of microglia polarization through an mTOR-autophagy-dependent pathway
X Zhuang, Y Yu, Y Jiang, S Zhao, Y Wang, L Su… - International …, 2020 - Elsevier
Sepsis-associated encephalopathy (SAE) is the cognitive impairment resulting from sepsis
and is associated with increased morbidity and mortality. Hydrogen has emerged as a …
and is associated with increased morbidity and mortality. Hydrogen has emerged as a …
Microglia in Alzheimer's disease: a target for immunotherapy
Microglia are resident Mϕs of the CNS that play pleiotropic functions in brain development
and homeostasis. Impaired microglial functions are thought to be involved in the onset and …
and homeostasis. Impaired microglial functions are thought to be involved in the onset and …