Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited
arrhythmogenic disease occurring in patients with a structurally normal heart: the disease is …

Homeostatic control of the endoplasmic reticulum (ER) both as the site for protein handling
(synthesis, folding, trafficking, disaggregation and degradation) and as a Ca2+ store is of …

Cardiac ryanodine receptor (RyR2) gain-of-function mutations cause catecholaminergic
polymorphic ventricular tachycardia, a condition characterized by prominent ventricular …

The high-conductance intracellular calcium (Ca2+) channel RyR2 is essential for the
coupling of excitation and contraction in cardiac muscle. Among various modulators …

Objectives: The goal of this study was to establish a patient-specific human-induced
pluripotent stem cells (hiPSCs) model of catecholaminergic polymorphic ventricular …

Caffeine has long been used as a pharmacological probe for studying RyR (ryanodine
receptor)-mediated Ca2+ release and cardiac arrhythmias. However, the precise …

Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder.
Familial AD (FAD) mutations in presenilins have been linked to calcium (Ca2+) signaling …

Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

Regulation of calcium flux in the heart is a key process that affects cardiac excitability and
contractility. Degenerative diseases, such as coronary artery disease, have long been …

Rationale: Naturally occurring mutations in the cardiac ryanodine receptor (RyR2) have
been associated with both cardiac arrhythmias and cardiomyopathies. It is clear that delayed …