Neural respiratory drive, ie, the activity of respiratory centres controlling breathing, is an
overlooked physiologic variable which affects the pathophysiology and the clinical outcome …

Purpose To identify, describe and discuss the parameters used to predict weaning from
mechanical ventilation and extubation outcomes. Methods Systematic review of scientific …

Evidence has accumulated that respiratory muscle dysfunction develops in critically ill
patients and contributes to prolonged weaning from mechanical ventilation. Accordingly, it …

The term" weaning" is used to describe the gradual process of decreasing ventilator support.
It is estimated that 40% of the duration of mechanical ventilation is dedicated to the process …

Background The physiological effects of high-flow nasal cannula O 2 therapy (HFNC) have
been evaluated mainly in patients with hypoxemic respiratory failure. In this study, we …

Objectives: To calculate an index (termed Pmusc/Eadi index) relating the pressure
generated by the respiratory muscles (Pmusc) to the electrical activity of the diaphragm …

Muscular weakness and muscle wasting may often be observed in critically ill patients on
intensive care units (ICUs) and may present as failure to wean from mechanical ventilation …

Background Prolonged controlled mechanical ventilation depresses diaphragmatic
efficiency. Assisted modes of ventilation should improve it. We assessed the impact of …

Pompe disease is due to mutations in the gene encoding the lysosomal enzyme acid α-
glucosidase (GAA). Absence of functional GAA typically results in cardiorespiratory failure in …

Background Diaphragm dysfunction and its effects on outcomes of ventilator weaning have
been evaluated in mixed critical care populations using diaphragm thickening fraction (the …