Old fusidane-type antibiotics for new challenges: Chemistry and biology
T Chuan, W Ke, X Zhang, LI Gang… - Chinese Journal of …, 2022 - Elsevier
The spread of antibiotic-resistant bacteria and exhausted drug leads render some infections
untreatable now and in the future. To deal with these “new challenges”, scientists tend to re …
untreatable now and in the future. To deal with these “new challenges”, scientists tend to re …
Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012
S Limbadri, X Luo, X Lin, S Liao, J Wang, X Zhou… - Molecules, 2018 - mdpi.com
Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-
cephalosporin P1 (6) along with five known compounds (3–5, 7, 8) were isolated from deep …
cephalosporin P1 (6) along with five known compounds (3–5, 7, 8) were isolated from deep …
Biosynthetic Study of Cephalosporin P1 Reveals a Multifunctional P450 Enzyme and a Site-Selective Acetyltransferase
ZQ Cao, JM Lv, Q Liu, SY Qin, GD Chen… - ACS Chemical …, 2019 - ACS Publications
Fusidane-type antibiotics are a group of triterpenoid antibiotics. They include helvolic acid,
fusidic acid, and cephalosporin P1, among which fusidic acid has been used clinically. We …
fusidic acid, and cephalosporin P1, among which fusidic acid has been used clinically. We …
Synthesis and biological evaluation of novel fusidic acid derivatives as two-in-one agent with potent antibacterial and anti-inflammatory activity
B Tu, N Cao, B Zhang, W Zheng, J Li, X Tang, K Su, J Li… - Antibiotics, 2022 - mdpi.com
Fusidic acid (FA), a narrow-spectrum antibiotics, is highly sensitive to various Gram-positive
cocci associated with skin infections. It has outstanding antibacterial effects against certain …
cocci associated with skin infections. It has outstanding antibacterial effects against certain …
Research, development and pharmacological activity of fusidic acid and its derivatives
X Huang, QK Shen, HY Guo, ZS Quan, X Li - Journal of Molecular Structure, 2023 - Elsevier
Fusidic acid is a tetracyclic triterpenoid isolated from fungi. Fusidic acid has a wide range of
pharmacological activities, including anti-inflammatory, antimalarial, antiparasitic and …
pharmacological activities, including anti-inflammatory, antimalarial, antiparasitic and …
High‐yield strain of fusidic acid obtained by atmospheric and room temperature plasma mutagenesis and the transcriptional changes involved in improving its …
WW Huang, XY Ge, Y Huang, XT Chai… - Journal of Applied …, 2021 - academic.oup.com
Aims To obtain the high‐yield strain of fusidic acid, which is produced from fungus Fusidium
coccineum and is the only fusidane‐type antibiotic that has been used clinically, and confirm …
coccineum and is the only fusidane‐type antibiotic that has been used clinically, and confirm …
Structure and dynamics of microbial communities associated with the resurrection plant Boea hygrometrica in response to drought stress
RZ Sun, YY Wang, XQ Liu, ZL Yang, X Deng - Planta, 2024 - Springer
Main conclusion The resurrection plant Boea hygrometrica selectively recruits and
assembles drought-specific microbial communities across the plant–soil compartments …
assembles drought-specific microbial communities across the plant–soil compartments …
Characterization of three tailoring enzymes in dutomycin biosynthesis and generation of a potent antibacterial analogue
The anthracycline natural product dutomycin and its precursor POK-MD1 were isolated from
Streptomyces minoensis NRRL B-5482. The dutomycin biosynthetic gene cluster was …
Streptomyces minoensis NRRL B-5482. The dutomycin biosynthetic gene cluster was …
Identification of Cyclic Depsipeptides and Their Dedicated Synthetase from Hapsidospora irregularis
Seven cyclic depsipeptides were isolated from Hapsidospora irregularis and structurally
characterized as the calcium channel blocker leualacin and six new analogues based on …
characterized as the calcium channel blocker leualacin and six new analogues based on …