The diverse clinico-and histopathological features, frequency of transmission and treatment
outcome of Mycobacterium tuberculosis have been associated with several environmental …

Our understanding of Mycobacterium tuberculosis DNA repair mechanisms is still poor
compared with that of other bacterial organisms. However, the publication of the first …

ABSTRACT The Beijing family of Mycobacterium tuberculosis strains is part of lineage 2
(also known as the East Asian lineage). In clinical studies, we have observed that isolates …

Heritable hypermutation in bacteria is mainly due to alterations in the methyl-directed
mismatch repair (MMR) system. MMR-deficient strains have been described from several …

We developed a new multiplexed-PCR assay to accurately classify Mycobacterium
tuberculosis complex (MTC) isolates at the sublineage level by single nucleotide …

Alkylating agents, which are widespread in the environment, also occur endogenously as
primary and secondary metabolites. Such compounds have intrinsically extremely cytotoxic …

The ada operon of Mycobacterium tuberculosis, which encodes a composite protein of AdaA
and AlkA and a separate AdaB/Ogt protein, was characterized. M. tuberculosis treated with …

Fundamental aspects of the lifestyle of Mycobacterium tuberculosis implicate DNA
metabolism in bacillary survival and adaptive evolution. The environments encountered by …

Background Computer-assisted analyses have shown that all bacterial genomes contain a
small percentage of open reading frames with a frameshift or in-frame stop codon We report …

Nucleotide excision repair (henceforth abbreviated as NER) plays a pivotal role in all
organisms to protect their genetic material against radiations, toxic chemicals, and normal by …