Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans

DHJ Thijssen, RM Bruno, ACCM van Mil… - European heart …, 2019 - academic.oup.com
Endothelial dysfunction is involved in the development of atherosclerosis, which precedes
asymptomatic structural vascular alterations as well as clinical manifestations of …

Assessment of flow-mediated dilation in humans: a methodological and physiological guideline

DHJ Thijssen, MA Black, KE Pyke… - American Journal …, 2011 - journals.physiology.org
Endothelial dysfunction is now considered an important early event in the development of
atherosclerosis, which precedes gross morphological signs and clinical symptoms. The …

Arterial structure and function in vascular ageing: are you as old as your arteries?

DHJ Thijssen, SE Carter, DJ Green - The Journal of physiology, 2016 - Wiley Online Library
Advancing age may be the most potent independent predictor of future cardiovascular
events, a relationship that is not fully explained by time‐related changes in traditional …

Noninvasive assessment of subclinical atherosclerosis in children and adolescents: recommendations for standard assessment for clinical research: a scientific …

EM Urbina, RV Williams, BS Alpert, RT Collins… - …, 2009 - Am Heart Assoc
Deterioration in endothelial function and arterial stiffness are early events in the
development of cardiovascular diseases. In adults, noninvasive measures of atherosclerosis …

Wall shear stress–an important determinant of endothelial cell function and structure–in the arterial system in vivo: discrepancies with theory

RS Reneman, T Arts, APG Hoeks - Journal of vascular research, 2006 - karger.com
It has been well established that wall shear stress is an important determinant of endothelial
cell function and gene expression as well as of its structure. There is increasing evidence …

Vascular adaptation in athletes: is there an 'athlete's artery'?

DJ Green, A Spence, N Rowley… - Experimental …, 2012 - Wiley Online Library
Whilst the existence of a specific phenotype characterized as 'athlete's heart'is generally
acknowledged, the question of whether athletes exhibit characteristic vascular adaptations …

Relationship between flow-mediated vasodilation and cardiovascular risk factors in a large community-based study

T Maruhashi, J Soga, N Fujimura, N Idei, S Mikami… - Heart, 2013 - heart.bmj.com
Objective To determine the relationships between flow-mediated vasodilation (FMD) and
cardiovascular risk factors, and to evaluate confounding factors for measurement of FMD in …

Large variations in absolute wall shear stress levels within one species and between species

C Cheng, F Helderman, D Tempel, D Segers, B Hierck… - Atherosclerosis, 2007 - Elsevier
Wall shear stress (WSS), the frictional force between blood and endothelium, is an important
determinant of vascular function. It is generally assumed that WSS remains constant at a …

Wall shear stress as measured in vivo: consequences for the design of the arterial system

RS Reneman, APG Hoeks - Medical & biological engineering & computing, 2008 - Springer
Based upon theory, wall shear stress (WSS), an important determinant of endothelial
function and gene expression, has been assumed to be constant along the arterial tree and …

The percentage flow-mediated dilation index: A large-sample investigation of its appropriateness, potential for bias and causal nexus in vascular medicine

G Atkinson, AM Batterham - Vascular medicine, 2013 - journals.sagepub.com
The percentage flow-mediated dilation index (FMD%) scales the increase in arterial
diameter (Ddiff) as a constant proportion of baseline artery diameter (Dbase). We have …