Background Seasonal influenza virus is a common cause of acute lower respiratory infection
(ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated …

Antimicrobial resistance extracts high morbidity, mortality and economic costs yearly by
rendering bacteria immune to antibiotics. Identifying and understanding antimicrobial …

Antimicrobial resistance (AMR) is one of the most important health threats globally. The
ability to accurately identify resistant bacterial isolates and the individual antimicrobial …

Complete and accurate genome assemblies form the basis of most downstream genomic
analyses and are of critical importance. Recent genome assembly projects have relied on a …

For half a century population genetics studies have put type II restriction endonucleases to
work. Now, coupled with massively‐parallel, short‐read sequencing, the family of RAD …

A mysterious feature of Crohn's disease (CD) is the extra-intestinal manifestation of"
creeping fat"(CrF), defined as expansion of mesenteric adipose tissue around the inflamed …

Existing long-read assemblers require thousands of central processing unit hours to
assemble a human genome and are being outpaced by sequencing technologies in terms of …

Long-read sequencing technologies have substantially improved the assemblies of many
isolate bacterial genomes as compared to fragmented short-read assemblies. However …

The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from
carbohydrate fermentation, and deficiency in SCFA production is associated with type 2 …

Annotating newly sequenced genomes and determining alternative isoforms from long-read
RNA data are complex and incompletely solved problems. Here we present IsoQuant—a …