Human viral oncogenesis: a cancer hallmarks analysis

EA Mesri, MA Feitelson, K Munger - Cell host & microbe, 2014 - cell.com
Approximately 12% of all human cancers are caused by oncoviruses. Human viral
oncogenesis is complex, and only a small percentage of the infected individuals develop …

Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma

A Arzumanyan, HM Reis, MA Feitelson - Nature Reviews Cancer, 2013 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …

Patients with chronic hepatitis B treated with oral antiviral therapy retain a higher risk for HCC compared with patients with inactive stage disease

JY Cho, YH Paik, W Sohn, HC Cho, GY Gwak, MS Choi… - Gut, 2014 - gut.bmj.com
Background It is generally stated that oral antiviral therapy in patients with chronic hepatitis
B (CHB) decreases the risk of developing hepatocellular carcinoma (HCC). Although oral …

The direct and indirect roles of HBV in liver cancer: prospective markers for HCC screening and potential therapeutic targets

M Ringelhan, T O'Connor, U Protzer… - The Journal of …, 2015 - Wiley Online Library
Chronic hepatitis B virus (HBV) infection remains the number one risk factor for
hepatocellular carcinoma (HCC), accounting for more than 600 000 deaths/year. Despite …

Hepatitis B virus X gene and hepatocarcinogenesis

SA Ng, C Lee - Journal of gastroenterology, 2011 - Springer
Chronic hepatitis B virus (HBV) infection has been identified as a major risk factor in
hepatocellular carcinoma (HCC), which is one of the most common cancers worldwide. The …

The hepatitis B virus (HBV) HBx protein activates AKT to simultaneously regulate HBV replication and hepatocyte survival

S Rawat, MJ Bouchard - Journal of virology, 2015 - Am Soc Microbiol
Chronic infection with hepatitis B virus (HBV) is a risk factor for developing liver diseases
such as hepatocellular carcinoma (HCC). HBx is a multifunctional protein encoded by the …

[HTML][HTML] Potential mechanisms of hepatitis B virus induced liver injury

M Suhail, H Abdel-Hafiz, A Ali, K Fatima… - World Journal of …, 2014 - ncbi.nlm.nih.gov
Chronic active hepatitis (CAH) is acknowledged as an imperative risk factor for the
development of liver injury and hepatocellular carcinoma. The histological end points of …

[HTML][HTML] Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma

A Medhat, A Arzumanyan, MA Feitelson - Oncotarget, 2021 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) is a human pathogen that has infected an estimated two billion
people worldwide. Despite the availability of highly efficacious vaccines, universal screening …

Hepatitis B virus x protein induces perinuclear mitochondrial clustering in microtubule-and Dynein-dependent manners

S Kim, HY Kim, S Lee, SW Kim, S Sohn, K Kim… - Journal of …, 2007 - Am Soc Microbiol
The hepatitis B virus (HBV) X protein (HBx) is thought to play a key role in HBV replication
and the development of liver cancer. It became apparent that HBx induces mitochondrial …

HBx-induced hepatic steatosis and apoptosis are regulated by TNFR1-and NF-κB-dependent pathways

JY Kim, EH Song, HJ Lee, YK Oh, KH Choi… - Journal of molecular …, 2010 - Elsevier
Hepatitis B virus X (HBx) protein is an important regulator of hepatic steatosis observed in
patients with hepatitis B virus; however, its underlying molecular mechanism remains …