Energetics of blood flow in cardiovascular disease: concept and clinical implications of adverse energetics in patients with a Fontan circulation

FM Rijnberg, MG Hazekamp, JJ Wentzel… - Circulation, 2018 - Am Heart Assoc
Visualization and quantification of the adverse effects of distorted blood flow are important
emerging fields in cardiology. Abnormal blood flow patterns can be seen in various …

Imaging for preintervention planning: pre-and post-Fontan procedures

MA Fogel, RH Khiabani… - Circulation: Cardiovascular …, 2013 - Am Heart Assoc
The SP approach that we developed requires patient-specific anatomy. Although static
steady-state free-precession CMR is the method presented, the reconstruction tools can be …

Effect of Fontan geometry on exercise haemodynamics and its potential implications

E Tang, ZA Wei, KK Whitehead, RH Khiabani… - Heart, 2017 - heart.bmj.com
Objective Exercise intolerance afflicts Fontan patients with total cavopulmonary connections
(TCPCs) causing a reduction in quality of life. Optimising TCPC design is hypothesised to …

Respiratory effects on Fontan circulation during rest and exercise using real-time cardiac magnetic resonance imaging

Z Wei, KK Whitehead, RH Khiabani, M Tree… - The Annals of thoracic …, 2016 - Elsevier
Background It is known that respiration modulates cavopulmonary flows, but little data
compare mean flows under breath-holding and free-breathing conditions to isolate the …

Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study

M Schäfer, BS Frank, SM Humphries… - American Journal …, 2020 - journals.physiology.org
The Fontan circulation is characterized as a nonpulsatile flow propagation without a
pressure-generating ventricle. However, flow through the Fontan circulation still exhibits …

Hemodynamic effects of implanting a unidirectional valve in the inferior vena cava of the Fontan circulation pathway: an in vitro investigation

A Santhanakrishnan, KO Maher… - American Journal …, 2013 - journals.physiology.org
The Fontan surgical procedure used for treating patients with single ventricle congenital
heart disorders results in a total cavopulmonary connection (TCPC) of the vena cavae to the …

Role of computational modelling in planning and executing interventional procedures for congenital heart disease

TC Slesnick - Canadian Journal of Cardiology, 2017 - Elsevier
Increasingly, computational modelling and numerical simulations are used to help plan
complex surgical and interventional cardiovascular procedures in children and young adults …

Haemodynamic impact of stent implantation for lateral tunnel Fontan stenosis: a patient-specific computational assessment

E Tang, DB McElhinney, M Restrepo… - Cardiology in the …, 2016 - cambridge.org
BackgroundThe physiological importance of the lateral tunnel stenosis in the Fontan
pathway for children with single ventricle physiology can be difficult to determine. The impact …

Non-dimensional physics of pulsatile cardiovascular networks and energy efficiency

B Yigit, K Pekkan - Journal of The Royal Society …, 2016 - royalsocietypublishing.org
In Nature, there exist a variety of cardiovascular circulation networks in which the energetic
ventricular load has both steady and pulsatile components. Steady load is related to the …

Improving the Fontan: Pre-surgical planning using four dimensional (4D) flow, bio-mechanical modeling and three dimensional (3D) printing

S Hegde, A Hsiao - Progress in Pediatric Cardiology, 2016 - Elsevier
While early and intermediate results of Fontan palliation have greatly improved the survival
and quality of life of patients with single ventricle physiology, late complications remain …