Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …

A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …

Cell-based therapies have the potential to revolutionize current treatments for diseases with
high prevalence and related economic and social burden. Unfortunately, clinical trials have …

Animal and preliminary human studies of adult cell therapy following acute myocardial
infarction have shown an overall improvement of cardiac function. Myocardial and vascular …

Mesenchymal stem cells (MSC) have generated a great amount of enthusiasm over the past
decade as a novel therapeutic paradigm for a variety of diseases. Currently, MSC based …

Organ fibrosis is characterized by the accumulation of disorganized and stiff extracellular
matrix (ECM) and represents the final stage of several life-threatening diseases. The …

Understanding the processes governing the ability of the heart to repair and regenerate after
injury is crucial for developing translational medical solutions. New avenues of exploration …

Among the various types of cell-to-cell signaling, paracrine signaling comprises those
signals that are transmitted over short distances between different cell types. In the human …

Mesenchymal stem cell (MSC) is an intensely studied stem cell type applied for cardiac
repair. For decades, the preclinical researches on animal model and clinical trials have …

Mesenchymal stem cells (MSCs) are self-renewing, multipotent progenitor cells with
multilineage potential to differentiate into cell types of mesodermal origin, such as …