Background Biological ageing is one of the principal risk factors for neurodegenerative
diseases. It is becoming increasingly clear that acceleration of DNA methylation age, as …

Background Molecular brain tumor diagnosis is usually dependent on tissue biopsies or
resections. This can pose several risks associated with anesthesia or neurosurgery …

Effective diagnosis, prognostication, and management of CNS malignancies traditionally
involves invasive brain biopsies that pose significant risk to the patient. Sampling and …

Purpose: Primary central nervous system (CNS) gliomas can be classified by characteristic
genetic alterations. In addition to solid tissue obtained via surgery or biopsy, cell-free DNA …

Diffuse gliomas are the most common primary brain malignancy in adults. Treatment is
usually multimodal, with surgery followed by radiotherapy and chemotherapy. There has …

Simple Summary We demonstrate that, in pediatric embryonal brain tumors, cell-free DNA
extracted from CSF can be used for whole exome sequencing (WES), with informative …

Background Gliomas are aggressive malignant tumors, with poor prognosis. There is an
unmet need for the discovery of new, non-invasive biomarkers for differential diagnosis …

Brain tumors represent some of the most aggressive malignancies. The latest WHO
Classification of Tumors of the Central Nervous System recognizes more than 100 primary …

Pediatric central nervous system tumors remain challenging to diagnose. Imaging
approaches do not provide sufficient detail to discriminate between different tumor types …

Background The utility of liquid biopsies is well documented in several extracranial and
intracranial (brain/leptomeningeal metastases, gliomas) tumors. Methods The RANO …