Trauma-induced coagulopathy
Uncontrolled haemorrhage is a major preventable cause of death in patients with traumatic
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
injury. Trauma-induced coagulopathy (TIC) describes abnormal coagulation processes that …
[HTML][HTML] Viscoelastic point-of-care testing to assist with the diagnosis, management and monitoring of haemostasis: a systematic review and cost-effectiveness …
P Whiting, M Al, M Westwood, IC Ramos, S Ryder… - 2015 - ncbi.nlm.nih.gov
Background: Patients with substantive bleeding usually require transfusion and/or (re-)
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …
operation. Red blood cell (RBC) transfusion is independently associated with a greater risk …
[PDF][PDF] Tranexamic acid: a clinical review
Blood loss and subsequent transfusions are associated with major morbidity and mortality.
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …
The use of antifibrinolytics can reduce blood loss in cardiac surgery, trauma, orthopedic …
Effect of thromboelastography (TEG®) and rotational thromboelastometry (ROTEM®) on diagnosis of coagulopathy, transfusion guidance and mortality in trauma …
Introduction The understanding of coagulopathies in trauma has increased interest in
thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate …
thromboelastography (TEG®) and thromboelastometry (ROTEM®), which promptly evaluate …
Hyperfibrinolysis, physiologic fibrinolysis, and fibrinolysis shutdown: the spectrum of postinjury fibrinolysis and relevance to antifibrinolytic therapy
BACKGROUND Fibrinolysis is a physiologic process maintaining patency of the
microvasculature. Maladaptive overactivation of this essential function (hyperfibrinolysis) is …
microvasculature. Maladaptive overactivation of this essential function (hyperfibrinolysis) is …
Overwhelming tPA release, not PAI-1 degradation, is responsible for hyperfibrinolysis in severely injured trauma patients
BACKGROUND Trauma-induced coagulopathy (TIC) is associated with a fourfold increased
risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly …
risk of mortality. Hyperfibrinolysis is a component of TIC, but its mechanism is poorly …
An update on the coagulopathy of trauma
M Maegele, H Schöchl, MJ Cohen - Shock, 2014 - journals.lww.com
Trauma remains the leading cause of death with bleeding as the primary cause of
preventable mortality during the first 24 h following trauma. When death occurs, it happens …
preventable mortality during the first 24 h following trauma. When death occurs, it happens …
Tranexamic acid in trauma: how should we use it?
LM Napolitano, MJ Cohen, BA Cotton… - Journal of Trauma …, 2013 - journals.lww.com
The CRASH-2 trial results have prompted trauma centers to contemplate whether
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …
tranexamic acid (TXA) should be added to their armamentarium for the treatment of bleeding …
Fibrinolysis greater than 3% is the critical value for initiation of antifibrinolytic therapy
MP Chapman, EE Moore, CR Ramos… - Journal of Trauma …, 2013 - journals.lww.com
BACKGROUND The acute coagulopathy of trauma is present in up to one third of patients by
the time of admission, and the recent CRASH-2 and MATTERs trials have focused …
the time of admission, and the recent CRASH-2 and MATTERs trials have focused …
Tranexamic acid administration to pediatric trauma patients in a combat setting: the pediatric trauma and tranexamic acid study (PED-TRAX)
BACKGROUND Early administration of tranexamic acid (TXA) has been associated with a
reduction in mortality and blood product requirements in severely injured adults. It has also …
reduction in mortality and blood product requirements in severely injured adults. It has also …