Next-generation sequencing has provided a more complete picture of the composition of the
human transcriptome indicating that much of the “blueprint” is a vastness of poorly …

It is estimated that more than 90% of the mammalian genome is transcribed as non-coding
RNAs. Recent evidences have established that these non-coding transcripts are not junk or …

Glycans modify lipids and proteins to mediate inter-and intramolecular interactions across all
domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge …

We introduce APEX-seq, a method for RNA sequencing based on direct proximity labeling of
RNA using the peroxidase enzyme APEX2. APEX-seq in nine distinct subcellular locales …

RNA-binding proteins play crucial roles in the regulation of gene expression, and
understanding the interactions between RNAs and RBPs in distinct cellular conditions forms …

RNA has emerged as the prime target for diagnostics, therapeutics and the development of
personalized medicine. In particular, the non-coding RNAs (ncRNAs) that do not encode …

RNA structure is intimately connected to each step of gene expression. Recent advances
have enabled transcriptome-wide maps of RNA secondary structure, called 'RNA …

Prior to the sequencing of the human genome, it was presumed that most of the DNA coded
for proteins. However, with the advent of next-generation sequencing, it has now been …

Interactions with RNA-binding proteins (RBPs) are integral to RNA function and cellular
regulation, and dynamically reflect specific cellular conditions. However, presently available …

Members of the mammalian AlkB family are known to mediate nucleic acid demethylation,.
ALKBH7, a mammalian AlkB homologue, localizes in mitochondria and affects metabolism …