SIRT1 is a highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent histone
deacetylase. It is involved in the regulation of various pathophysiological processes …

Fibroblasts do not only serve as matrix-producing reparative cells, but exhibit a wide range
of functions in inflammatory and immune responses, angiogenesis and neoplasia. The adult …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

One of the major therapeutic goals of modern cardiology is to design strategies aimed at
minimizing myocardial necrosis and optimizing cardiac repair following myocardial …

The term matricellular proteins describes a family of structurally unrelated extracellular
macromolecules that, unlike structural matrix proteins, do not play a primary role in tissue …

The CC chemokine Monocyte Chemoattractant Protein (MCP)-1/CCL2 has potent
mononuclear cell chemo-attractant properties, modulates fibroblast and endothelial cell …

Myocardial infarction is the most common cause of cardiac injury and results in acute loss of
a large number of myocardial cells. Because the heart has negligible regenerative capacity …

Cardiovascular regenerative therapies are pursued on both basic and translational levels.
Although efficacy and value of cell therapy for myocardial regeneration can be debated …

Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the
excessive generation or accumulation of free radicals or their oxidation products. Free …

Fibroblasts are the predominant cell type in the cardiac interstitium. As the main matrix-
producing cells in the adult mammalian heart, fibroblasts maintain the integrity of the …