Smart Nanoscale Extracellular Vesicles in the Brain: Unveiling their Biology, Diagnostic Potential, and Therapeutic Applications

A Onkar, F Khan, A Goenka… - … Applied Materials & …, 2024 - ACS Publications
Information exchange is essential for the brain, where it communicates the physiological and
pathological signals to the periphery and vice versa. Extracellular vesicles (EVs) are a …

[HTML][HTML] Extracellular vesicles: The next generation of biomarkers and treatment for central nervous system diseases

G Zanirati, PG Dos Santos, AM Alcará, F Bruzzo… - International Journal of …, 2024 - mdpi.com
It has been widely established that the characterization of extracellular vesicles (EVs),
particularly small EVs (sEVs), shed by different cell types into biofluids, helps to identify …

Serum tau, neurofilament light chain, glial fibrillary acidic protein, and ubiquitin carboxyl-terminal hydrolase L1 are associated with the chronic deterioration of …

RT Lange, S Lippa, TA Brickell, J Gill… - Journal of …, 2023 - liebertpub.com
The purpose of this study was to examine the association of serum tau, neurofilament light
chain (NFL), glial fibrillary acidic protein (GFAP), and ubiquitin carboxy-terminal hydrolase …

Integrated multiomics analysis of salivary exosomes to identify biomarkers associated with changes in mood states and fatigue

W Cohn, C Zhu, J Campagna, T Bilousova… - International journal of …, 2022 - mdpi.com
Fatigue and other deleterious mood alterations resulting from prolonged efforts such as a
long work shift can lead to a decrease in vigilance and cognitive performance, increasing …

Characteristics and Neural Mechanisms of Sleep–Wake Disturbances After Traumatic Brain Injury

G Yan, Y Wei, D Wang, D Wang, H Ren… - Journal of …, 2024 - liebertpub.com
Sleep–wake disturbances (SWDs) are one of the most common complaints following
traumatic brain injury (TBI). The high prevalence and socioeconomic burden of SWDs post …

Neurological symptoms and their associations with inflammatory biomarkers in the chronic phase following traumatic brain injuries

G Li, H Liu, Y He, Z Hu, Y Gu, Y Li, Y Ye, J Hu - Frontiers in Psychiatry, 2022 - frontiersin.org
Background The underlying biological mechanisms for neurological symptoms following a
traumatic brain injury (TBI) remain poorly understood. This study investigated the …

Elevated serum tau and UCHL-1 concentrations within 12 months of injury predict neurobehavioral functioning 2 or more years following traumatic brain injury: A …

RT Lange, JM Gill, SM Lippa… - The Journal of head …, 2024 - journals.lww.com
Objective: Blood-based biomarkers have received considerable attention for their diagnostic
and prognostic value in the acute and postacute period following traumatic brain injury (TBI) …

Clinical Efficacy and Mechanistic Insights of Anshen Dingzhi Prescription on Breast Cancer-Related PTSD Through Network Pharmacology and Molecular Docking

H Zhang, Y Zhu, G Zhu, S Yang - Integrative Cancer …, 2024 - journals.sagepub.com
Anshen Dingzhi prescription (ADP) is a classic prescription of traditional Chinese medicine,
which has been used in the treatment of neuropsychiatric diseases. However, its treatment …

Association of Biomarkers of Neuronal Injury and Inflammation With Insomnia Trajectories After Traumatic Brain Injury: A TRACK-TBI Study

JK Werner, J Albrecht, VF Capaldi, S Jain, X Sun… - Neurology, 2024 - AAN Enterprises
Background and Objectives Insomnia affects about one-third of patients with traumatic brain
injury and is associated with worsened outcomes after injury. We hypothesized that higher …

Traumatic brain injury and sleep in military and veteran populations: A literature review

J Landvater, S Kim, K Caswell, C Kwon… - …, 2024 - content.iospress.com
BACKGROUND: Traumatic brain injury (TBI) is a hallmark of wartime injury and is related to
numerous sleep wake disorders (SWD), which persist long term in veterans. Current …