This article provides a comprehensive, up-to-date review of methods to prevent early and
late renal-allograft loss and to improve long-term outcomes in patients. The authors focus …

Since the introduction of organ transplantation into medical practice, progress and optimism
have been abundant. Improvements in immunosuppressive drugs and ancillary care have …

Five patients with end-stage renal disease received combined bone marrow and kidney
transplants from HLA single-haplotype mismatched living related donors, with the use of a …

We report here the long-term results of HLA-mismatched kidney transplantation without
maintenance immunosuppression (IS) in 10 subjects following combined kidney and bone …

Many strategies have been proposed to induce tolerance to transplanted tissue in rodents;
however, few if any have shown equal efficacy when tested in nonhuman primate transplant …

The discrepancy between organ need and organ availability represents one of the major
limitations in the field of transplantation. One possible solution to this problem is …

In less than 50 years the field of organ transplantation has transitioned from an experimental
concept to clinical commonplace. Notwithstanding the dramatic improvements in patient and …

Costimulatory blockade with anti-CD154 monoclonal antibody (aCD154) prolongs allograft
survival in nonhuman primates, but has not reliably induced tolerance when used alone. In …

“Mixed chimerism” refers to a state in which the lymphohematopoietic system of the recipient
of allogeneic hematopoietic stem cells comprises a mixture of host and donor cells. This …

Mesenchymal stem cells (MSCs) express low immunogenicity and demonstrate
immunomodulatory properties in vitro that may safely allow their transplantation into …