Lipid droplets and fatty acid‐induced lipotoxicity: in a nutshell
Lipid droplets (LDs) are fat storage organelles that are conserved from bacteria to humans.
LDs are broken down to supply cells with fatty acids (FAs) that can be used as an energy …
LDs are broken down to supply cells with fatty acids (FAs) that can be used as an energy …
The key role of altered tubule cell lipid metabolism in kidney disease development
Kidney epithelial cells have very high energy requirements, which are largely met by fatty
acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney …
acid oxidation. Complex changes in lipid metabolism are observed in patients with kidney …
Promotion of neuroinflammation by the glymphatic system: a new insight into ethanol extracts from Alisma orientale in alleviating obesity-associated cognitive …
M Zhan, X Liu, X Xia, Y Yang, Y Xie, L Zhang, C Lin… - Phytomedicine, 2024 - Elsevier
Background Obesity is one of the critical risk factors for cognitive dysfunction. The
glymphatic system (GS) plays a key role in the pathogenesis of cognitive deficits. Alisma …
glymphatic system (GS) plays a key role in the pathogenesis of cognitive deficits. Alisma …
[HTML][HTML] Lipotoxicity as a therapeutic target in obesity and diabetic cardiomyopathy
M Nakamura - Journal of Pharmacy & Pharmaceutical …, 2024 - frontierspartnerships.org
Unhealthy sources of fats, ultra-processed foods with added sugars, and a sedentary
lifestyle make humans more susceptible to developing overweight and obesity. While lipids …
lifestyle make humans more susceptible to developing overweight and obesity. While lipids …
Stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response.
K Yamanoi, J Ogura, E Nakamura… - Journal of …, 2024 - search.ebscohost.com
Objective: High-fat diets are implicated in the progression of cancer, but reports suggest that
the impact varies depending on the type of fat, such as saturated and unsaturated fatty acids …
the impact varies depending on the type of fat, such as saturated and unsaturated fatty acids …
PAQR proteins and the evolution of a superpower: Eating all kinds of fats: Animals rely on evolutionarily conserved membrane homeostasis proteins to compensate for …
Recently published work showed that members of the PAQR protein family are activated by
cell membrane rigidity and contribute to our ability to eat a wide variety of diets. Cell …
cell membrane rigidity and contribute to our ability to eat a wide variety of diets. Cell …
Lipotoxicity Induces Beta Cell Small Extracellular Vesicle-mediated Beta Cell Dysfunction
A Roy, A Hoff, TK Her, G Ariyaratne… - bioRxiv, 2024 - biorxiv.org
Chronically elevated circulating excess free fatty acids (ie lipotoxicity) is a pathological
process implicated in several metabolic disorders, including obesity-driven Type 2 diabetes …
process implicated in several metabolic disorders, including obesity-driven Type 2 diabetes …
Unravelling neuronal and glial differences in ceramide composition, synthesis, and sensitivity to toxicity
JJ McInnis, D Sood, L Guo, MR Dufault, M Garcia… - bioRxiv, 2023 - biorxiv.org
Ceramides are lipids that play vital roles in complex lipid synthesis, membrane function, and
cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several …
cell signaling. Disrupted ceramide homeostasis is implicated in cell-death and several …
Stearate-rich diet and oleate restriction directly inhibit tumor growth via the unfolded protein response
Y Koji, O Jumpei, N Eijiro, I Shinji, N Yuki, M Toshi… - 2024 - researchsquare.com
Fatty acids are known to have a significant impact on the properties of cancer cells.
Therefore, Incorporating them into therapeutic strategies has been reported. However, few …
Therefore, Incorporating them into therapeutic strategies has been reported. However, few …