Developing bioorthogonal probes to span a spectrum of reactivities

SS Nguyen, JA Prescher - Nature Reviews Chemistry, 2020 - nature.com
Bioorthogonal chemistries enable researchers to interrogate biomolecules in living systems.
These reactions are highly selective and biocompatible, and can be performed in many …

Development and application of bond cleavage reactions in bioorthogonal chemistry

J Li, PR Chen - Nature Chemical Biology, 2016 - nature.com
Bioorthogonal chemical reactions are a thriving area of chemical research in recent years as
an unprecedented technique to dissect native biological processes through chemistry …

Selective chemical labeling of proteins

X Chen, YW Wu - Organic & biomolecular chemistry, 2016 - pubs.rsc.org
Over the years, there have been remarkable efforts in the development of selective protein
labeling strategies. In this review, we deliver a comprehensive overview of the currently …

Visible light-initiated bioorthogonal photoclick cycloaddition

J Li, H Kong, L Huang, B Cheng, K Qin… - Journal of the …, 2018 - ACS Publications
Here we report a visible light-triggered, catalyst free bioorthogonal reaction that proceeds
via a distinct pathway from reported bioorthogonal reactions. The prototype of this …

Orthogonal bioorthogonal chemistries

DM Patterson, JA Prescher - Current opinion in chemical biology, 2015 - Elsevier
Highlights•Mutually orthogonal bioorthogonal reactions are described.•Current challenges
in compatible reaction development are outlined.•Strategies to identify and generate …

Inverse electron-demand Diels–Alder bioorthogonal reactions

H Wu, NK Devaraj - Cycloadditions in Bioorthogonal Chemistry, 2016 - Springer
Bioorthogonal reactions have been widely used over the last 10 years for imaging,
detection, diagnostics, drug delivery, and biomaterials. Tetrazine reactions are a recently …

ortho‐Quinones and Analogues Thereof: Highly Reactive Intermediates for Fast and Selective Biofunctionalization

JJ Bruins, B Albada, F van Delft - Chemistry–A European …, 2018 - Wiley Online Library
Fast, selective and facile functionalization of biologically relevant molecules is a pursuit of
ever‐growing importance. A promising approach in this regard employs the high reactivity of …

Recent developments and strategies for mutually orthogonal bioorthogonal reactions

Y Hu, JM Schomaker - ChemBioChem, 2021 - Wiley Online Library
Over the past decade, several different metal‐free bioorthogonal reactions have been
developed to enable simultaneous double‐click labeling with minimal‐to‐no competing …

Cycloaddition reactions of o-quinone methides with polarized olefins

VA Osyanin, AV Lukashenko… - Russian Chemical …, 2021 - iopscience.iop.org
The review summarizes and systematizes the [4+ 2]-cycloaddition reactions of o-quinone
methides with electron-rich and electron-deficient olefins. The electron-rich substrates …

Dissecting programmed cell death with small molecules

Y Bai, HC Lam, X Lei - Accounts of Chemical Research, 2020 - ACS Publications
Conspectus Programmed cell death (PCD) is fundamentally an indispensable process in all
cellular activities, including cell development, wound healing, and immune surveillance of …