Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …

Tau is a microtubule-associated protein that has a role in stabilizing neuronal microtubules
and thus in promoting axonal outgrowth. Structurally, tau is a natively unfolded protein, is …

Neuronal intranuclear inclusion disease (NIID) is a slowly progressing neurodegenerative
disease characterized by eosinophilic intranuclear inclusions in the nervous system and …

Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disease
characterized by the presence of intranuclear inclusions of unknown origin. NIID is caused …

Huntington's disease (HD) is characterized by the accumulation of a pathogenic protein,
Huntingtin (Htt), that contains an abnormal polyglutamine expansion. Here, we report that a …

The small ubiquitin-related modifier SUMO posttranslationally modifies many proteins with
roles in diverse processes including regulation of transcription, chromatin structure, and …

Intracellular accumulation of the abnormally modified tau is hallmark pathology of
Alzheimer's disease (AD), but the mechanism leading to tau aggregation is not fully …

Sumoylation is an important post-translational modification that provides a rapid and
reversible means for controlling the activity, subcellular localization, and stability of target …

Protein SUMOylation is a critically important posttranslational protein modification that
participates in nearly all aspects of cellular physiology. In the nearly 20 years since its …

SUMO (small ubiquitin-related modifier) family proteins are not only structurally but also
mechanistically related to ubiquitin in that they are posttranslationally attached to other …