Osteoarthritis (OA) is a degenerative joint disease characterized by low-grade inflammation
and high levels of clinical heterogeneity. Aberrant chondrocyte metabolism is a response to …

Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Objective The aim of the study was to investigate the role and regulatory mechanisms of
fibroblast-like synoviocytes (FLSs) and their senescence in the progression of osteoarthritis …

Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Osteoarthritis (OA), is a major cause of severe joint pain, physical disability and quality of life
impairment in the aging population across the developed and developing world. Increased …

Apoptosis is a highly-regulated, active process of cell death involved in development,
homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as …

Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Osteoarthritis (OA) is an age-related cartilage degenerative disease, and chondrocyte
senescence has been extensively studied in recent years. Increased numbers of senescent …

Introduction Osteoarthritis (OA) is one of the most common forms of arthritis. There is
accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial …