Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Peripheral nerve and brachial plexus injuries typically cause severe impairment in the
affected limb. The incidence of neuropathic pain is high, reaching up to 95% of cases …

This study investigated the role of TRPA1 in the development and maintenance of
mechanical and cold hyperalgesia in persistent inflammation induced by Complete Freund's …

The management of neuropathic pain is still a major challenge because of its
unresponsiveness to most common treatments. Curcumin has been reported to play an …

It has been shown that following peripheral nerve injury brain-derived neurotrophic factor
(BDNF) released by activated microglia contributes to neuropathic pain, but whether BDNF …

Neurotrophins (NTs) belong to a family of structurally and functionally related proteins, they
are the subsets of neurotrophic factors. Neurotrophins are responsible for diverse actions in …

Pain is a complex experience, encompassing physiological and psychological components.
Amongst the different types of pain, neuropathic pain, resulting from injuries to the peripheral …

Activation of primary afferent nociceptors produces acute, short-lived pain, and tissue or
nerve injury induces long-term enhancement of nociceptive processing, manifested as …

We review our experience treating 335 adult patients with supraclavicular brachial plexus
injuries over a 7-year period at the University of Southern Santa Catarina, in Brazil. Patients …

Injury typically results in the development of neuropathic pain, but the pain normally
decreases and disappears in paralleled with wound healing. The pain results from cells …