Transforming growth factor-beta (TGF-β)/bone morphogenetic protein (BMP) plays a
fundamental role in the regulation of bone organogenesis through the activation of receptor …

The balance between bone forming cells (osteoblasts/osteocytes) and bone resorbing cells
(osteoclasts) plays a crucial role in tissue homeostasis and bone repair. Several hormones …

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by
extraskeletal bone formation through endochondral ossification. FOP patients harbor point …

Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal-dominant disorder
characterized by progressive and profoundly disabling heterotopic ossification (HO). Here …

Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO)
syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I …

Bone morphogenetic proteins (BMPs) are cytokines belonging to the transforming growth
factor-β (TGF-β) superfamily. They play multiple functions during development and tissue …

Heterotopic ossification is a debilitating condition that can result from traumatic injury,
surgery, or genetic disease. We investigated the cellular origins of heterotopic …

Human disorders of hereditary and nonhereditary heterotopic ossification are conditions in
which osteogenesis occurs outside of the skeleton, within soft tissues of the body. The …

Fibrodysplasia ossificans progressiva (FOP), a rare and disabling genetic condition
characterized by congenital malformations of the great toes and progressive heterotopic …

In normal healthy individuals, mineral formation is restricted to specialized tissues which
form the skeleton and the dentition. Within these tissues, mineral formation is tightly …