Congenital myopathies: disorders of excitation–contraction coupling and muscle contraction
The congenital myopathies are a group of early-onset, non-dystrophic neuromuscular
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …
conditions with characteristic muscle biopsy findings, variable severity and a stable or slowly …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
Structure determination of membrane proteins by NMR spectroscopy
SJ Opella, FM Marassi - Chemical reviews, 2004 - ACS Publications
Much of postgenomic biochemistry and all of structural biology are based on the premise
that the starting point for both understanding specific biochemical processes, such as affinity …
that the starting point for both understanding specific biochemical processes, such as affinity …
Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy
OC Andronesi, S Becker, K Seidel… - Journal of the …, 2005 - ACS Publications
It is shown that molecular structure and dynamics of a uniformly labeled membrane protein
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …
can be studied under magic-angle-spinning conditions. For this purpose, dipolar recoupling …
The structure of phospholamban pentamer reveals a channel-like architecture in membranes
K Oxenoid, JJ Chou - … of the National Academy of Sciences, 2005 - National Acad Sciences
Contraction and relaxation of heart muscle cells is regulated by cycling of calcium between
cytoplasm and sarcoplasmic reticulum. Human phospholamban (PLN), expressed in the …
cytoplasm and sarcoplasmic reticulum. Human phospholamban (PLN), expressed in the …
Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms
This paper reviews various enhanced conformational sampling methods and explicit/implicit
solvent/membrane models, as well as their recent applications to the exploration of the …
solvent/membrane models, as well as their recent applications to the exploration of the …
Structural topology of phospholamban pentamer in lipid bilayers by a hybrid solution and solid-state NMR method
Phospholamban (PLN) is a type II membrane protein that inhibits the sarcoplasmic reticulum
Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In …
Ca2+-ATPase (SERCA), thereby regulating calcium homeostasis in cardiac muscle. In …
NMR structure of the cathelicidin-derived human antimicrobial peptide LL-37 in dodecylphosphocholine micelles
LL-37 is the only cathelicidin-derived polypeptide found in humans. Its eclectic function
makes this peptide one of the most intriguing chemical defense agents, with crucial roles in …
makes this peptide one of the most intriguing chemical defense agents, with crucial roles in …
Structures of Rat and Human Islet Amyloid Polypeptide IAPP1−19 in Micelles by NMR Spectroscopy
Disruption of the cellular membrane by the amyloidogenic peptide IAPP (or amylin) has
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …
been implicated in β-cell death during type 2 diabetes. While the structure of the mostly inert …
Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach
Phospholamban (PLN) is an essential regulator of cardiac muscle contractility. The
homopentameric assembly of PLN is the reservoir for active monomers that, upon …
homopentameric assembly of PLN is the reservoir for active monomers that, upon …