Autophagy is a conserved lysosomal degradation pathway where cellular components are
dynamically degraded and re-processed to maintain physical homeostasis. However, the …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

EGLN3 is critically important for growth of various cancers including lung cancer. However,
virtually nothing is known about the role and mechanism for EGLN3 hydroxylase activity in …

Macroautophagy/autophagy is an evolutionarily highly conserved catabolic process that is
important for the clearance of cytosolic contents to maintain cellular homeostasis and …

Historical and demographical human cohorts of populations exposed to famine, as well as
animal studies, revealed that exposure to food deprivation is associated to lasting health …

Background Energy balance has long been known to extend lifespans and inhibit
carcinogenesis in multiple species by slowing age‐related epigenetic changes while the …

Autophagy is an intracellular mechanism that maintains cellular homeostasis in different
tissues. This process declines in cartilage due to aging, which is correlated with …

Macroautophagy/autophagy is an evolutionarily conserved and tightly regulated catabolic
process involved in the maintenance of cellular homeostasis whose dysregulation is …

Pulmonary hypertension is characterized by pulmonary arterial remodeling that results in
increased pulmonary vascular resistance, right ventricular failure, and premature death. It is …

Ferroptosis was first proposed in 2012, a new form of cell death. Autophagy plays a crucial
role in cell clearance and maintaining homeostasis. Autophagy is involved in the initial step …