Purpose The hypothalamic–pituitary–adrenal (HPA) axis exerts many actions on the central
nervous system (CNS) aside from stress regulation. Glucocorticoids (GCs) play an important …

Chronic exposure to high circulating levels of glucocorticoids has detrimental effects on
health, including metabolic abnormalities, as exemplified in Cushing's syndrome (CS) …

The neurochemical anatomy underlying Cushing's syndrome is examined for regional brain
metabolism as well as neurotransmitter levels and receptor binding of biogenic amines and …

The adverse effects of hypercortisolism on the human brain have been highlighted in
previous studies of Cushing's disease (CD). However, the relative alterations in regional …

Long-term remitted Cushing's disease (LTRCD) patients commonly continue to present
persistent psychological and cognitive deficits, and alterations in brain function and …

Purpose To compare thalamic volume and cognitive functions of patients with mild
autonomous cortisol secretion (MACS) with control subjects and patients with overt …

Cushings disease (CD) remains a diagnostic and therapeutic challenge. Different subtypes
may be recognized that will offer insight in this complex situation. We describe an atypical …

Background: Cushing's disease (CD) is defined by glucocorticoid excess secondary to the
increased section of corticotropin by a pituitary adenoma. Magnetic resonance imaging …

Crespo 2014 [6] 35 patients with CS (27 cured, 8 medically treated), 35 controls Volumetric
MRI No differences were found between cured and treated CS patients. Patients had …

In the present issue of The Journal of Clinical Endocrinology and Metabolism, Tirosh and
colleagues examined the consequences of hypercortisolism on the brain of young patients …