Periods of synchronized myelin changes shape brain function and plasticity

O de Faria Jr, H Pivonkova, B Varga, S Timmler… - Nature …, 2021 - nature.com
Myelin, a lipid membrane that wraps axons, enabling fast neurotransmission and metabolic
support to axons, is conventionally thought of as a static structure that is set early in …

Neuron-oligodendrocyte interactions in the structure and integrity of axons

GJ Duncan, TJ Simkins, B Emery - Frontiers in Cell and …, 2021 - frontiersin.org
The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

Adaptive and maladaptive myelination in health and disease

JK Knowles, A Batra, H Xu, M Monje - Nature Reviews Neurology, 2022 - nature.com
Within the past decade, multiple lines of evidence have converged to identify a critical role
for activity-regulated myelination in tuning the function of neural networks. In this Review, we …

Motor learning drives dynamic patterns of intermittent myelination on learning-activated axons

CM Bacmeister, R Huang, LA Osso, MA Thornton… - Nature …, 2022 - nature.com
Myelin plasticity occurs when newly formed and pre-existing oligodendrocytes remodel
existing patterns of myelination. Myelin remodeling occurs in response to changes in …

Oligodendrocyte calcium signaling promotes actin-dependent myelin sheath extension

M Iyer, H Kantarci, MH Cooper, N Ambiel… - Nature …, 2024 - nature.com
Myelin is essential for rapid nerve signaling and is increasingly found to play important roles
in learning and in diverse diseases of the CNS. Morphological parameters of myelin such as …

TET1-mediated DNA hydroxymethylation regulates adult remyelination in mice

S Moyon, R Frawley, D Marechal, D Huang… - Nature …, 2021 - nature.com
The mechanisms regulating myelin repair in the adult central nervous system (CNS) are
unclear. Here, we identify DNA hydroxymethylation, catalyzed by the Ten-Eleven …

Structural insights into the contactin 1–neurofascin 155 adhesion complex

LMP Chataigner, C Gogou, MA den Boer… - Nature …, 2022 - nature.com
Cell-surface expressed contactin 1 and neurofascin 155 control wiring of the nervous system
and interact across cells to form and maintain paranodal myelin-axon junctions. The …

[HTML][HTML] Experience-dependent myelination following stress is mediated by the neuropeptide dynorphin

LA Osso, KA Rankin, JR Chan - Neuron, 2021 - cell.com
Emerging evidence implicates experience-dependent myelination in learning and memory.
However, the specific signals underlying this process remain unresolved. We demonstrate …

Oligodendroglia are emerging players in several forms of learning and memory

M Munyeshyaka, RD Fields - Communications Biology, 2022 - nature.com
Synaptic plasticity is the fundamental cellular mechanism of learning and memory, but
recent research reveals that myelin-forming glia, oligodendrocytes (OL), are also involved …

[HTML][HTML] A little goes a long way: neurobiological effects of low intensity rTMS and implications for mechanisms of rTMS

J Moretti, J Rodger - Current Research in Neurobiology, 2022 - Elsevier
Repetitive transcranial magnetic stimulation (rTMS) is a widespread technique in
neuroscience and medicine, however its mechanisms are not well known. In this review, we …