Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to
tackle disease-causing proteins that have historically been highly challenging to target with …

Auxin, one of the first identified and most widely studied phytohormones, has been and will
remain a hot topic in plant biology. After more than a century of passionate exploration, the …

The phytohormone auxin is the major coordinative signal in plant development, mediating
transcriptional reprogramming by a well-established canonical signalling pathway …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

Abscisic acid (ABA) represses seed germination and postgerminative growth in Arabidopsis
thaliana. Auxin and jasmonic acid (JA) stimulate ABA function; however, the possible …

Ubiquitin E3 ligases control every aspect of eukaryotic biology by promoting protein
ubiquitination and degradation. At the end of a three-enzyme cascade, ubiquitin ligases …

This review focuses on the evolution of plant hormone signaling pathways. Like the
chemical nature of the hormones themselves, the signaling pathways are diverse. Therefore …

Experimental manipulation of protein abundance in living cells or organisms is an essential
strategy for investigation of biological regulatory mechanisms. Whereas powerful techniques …

Growth–defense tradeoffs are thought to occur in plants due to resource restrictions, which
demand prioritization towards either growth or defense, depending on external and internal …

Plants are under relentless challenge by pathogenic bacteria, fungi, and oomycetes, for
whom they provide a resource of living space and nutrients. Upon detection of pathogens …