Challenges in developing cell culture media using machine learning

T Hashizume, BW Ying - Biotechnology Advances, 2024 - Elsevier
Microbial and mammalian cells are widely used in the food, pharmaceutical, and medical
industries. Developing or optimizing culture media is essential to improve cell culture …

Therapeutic l-asparaginase: upstream, downstream and beyond

AM Lopes, L Oliveira-Nascimento… - Critical reviews in …, 2017 - Taylor & Francis
Abstract l-asparaginase (l-asparagine amino hydrolase, EC 3.5. 1.1) is an enzyme clinically
accepted as an antitumor agent to treat acute lymphoblastic leukemia and lymphosarcoma …

Optimization and techno-economic analysis of biodiesel production from Calophyllum inophyllum oil using heterogeneous nanocatalyst

R Naveenkumar, G Baskar - Bioresource Technology, 2020 - Elsevier
The present research work is aimed at reducing the consumption of reactants by process
optimization and economic analysis of large-scale commercial plant using techno-economic …

Fungal enzymes: sources and biotechnological applications

N Kango, UK Jana, R Choukade - … : Basic and Applied Aspects of Fungi, 2019 - Springer
Fungi, being obligate heterotrophs, are natural decomposers and elaborate a number of
enzymes. Currently, more than half of the industrial enzymes are of fungal origin and are …

Exploring current scenario and developments in the field of microbial L-asparaginase production and applications: A review

PG Patel, HZ Panseriya, AK Vala, BP Dave… - Process …, 2022 - Elsevier
L-asparaginase, an amidohydrolase that catalyses break down of L-asparagine into aspartic
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …

Harnessing QbD, programming languages, and automation for reproducible biology

MI Sadowski, C Grant, TS Fell - Trends in biotechnology, 2016 - cell.com
Building robust manufacturing processes from biological components is a task that is highly
complex and requires sophisticated tools to describe processes, inputs, and measurements …

Modelling the removal of volatile pollutants under transient conditions in a two-stage bioreactor using artificial neural networks

ME López, ER Rene, Z Boger, MC Veiga… - Journal of hazardous …, 2017 - Elsevier
A two-stage biological waste gas treatment system consisting of a first stage biotrickling filter
(BTF) and second stage biofilter (BF) was tested for the removal of a gas-phase methanol …

Optimization and purification of L-asparaginase from fungi: A systematic review

PM Souza, MM de Freitas, SL Cardoso… - Critical Reviews in …, 2017 - Elsevier
The purpose of this systematic review was to identify the available literature of the l-
asparaginase producing fungi. This study followed the Preferred Reporting Items for …

Comparison between developed models using response surface methodology (RSM) and artificial neural networks (ANNs) with the purpose to optimize …

G Astray, B Gullon, J Labidi, P Gullon - Industrial Crops and Products, 2016 - Elsevier
This work aimed the assessment of the use of artificial neural networks (ANNs) as alternative
tool for modelling and predicting the suitability of sugar beet pulp (SBP) to produce …

A review of algorithmic approaches for cell culture media optimization

T Zhou, R Reji, RS Kairon, KH Chiam - Frontiers in Bioengineering …, 2023 - frontiersin.org
Cell culture media composition and culture conditions play a crucial role in product yield,
quality and cost of production. Culture media optimization is the technique of improving …