The heterogeneity of cellular senescence: insights at the single-cell level
Senescent cells are highly associated with aging and pathological conditions and could be
targeted to slow the aging process. One commonly used marker to examine senescent cells …
targeted to slow the aging process. One commonly used marker to examine senescent cells …
[HTML][HTML] Chronic inflammation and the hallmarks of aging
Background Recently, the hallmarks of aging were updated to include dysbiosis, disabled
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
macroautophagy, and chronic inflammation. In particular, the low-grade chronic …
[HTML][HTML] Apoptotic stress causes mtDNA release during senescence and drives the SASP
Senescent cells drive age-related tissue dysfunction partially through the induction of a
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …
chronic senescence-associated secretory phenotype (SASP). Mitochondria are major …
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain
N Rachmian, S Medina, U Cherqui, H Akiva… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …
contributing factors, including brain inflammation. Microglia, and specifically those …
Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction
Senescent cells, which accumulate in organisms over time, contribute to age-related tissue
decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies …
decline. Genetic ablation of senescent cells can ameliorate various age-related pathologies …
Multiparametric senescent cell phenotyping reveals targets of senolytic therapy in the aged murine skeleton
Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …
Single-cell analysis identifies conserved features of immune dysfunction in simulated microgravity and spaceflight
Microgravity is associated with immunological dysfunction, though the mechanisms are
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …
poorly understood. Here, using single-cell analysis of human peripheral blood mononuclear …
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
Clearance of senescent cells (SnCs) can prevent several age-related pathologies, including
bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction …
bone loss. However, the local versus systemic roles of SnCs in mediating tissue dysfunction …
The senescence-associated secretory phenotype and its physiological and pathological implications
Cellular senescence is a state of terminal growth arrest associated with the upregulation of
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
different cell cycle inhibitors, mainly p16 and p21, structural and metabolic alterations …
Molecular mechanisms of vascular health: insights from vascular aging and calcification
Cardiovascular disease is the most common cause of death worldwide, especially beyond
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …
the age of 65 years, with the vast majority of morbidity and mortality due to myocardial …