Recognition of CD1d-restricted antigens by natural killer T cells
Natural killer T (NKT) cells are innate-like T cells that rapidly produce a variety of cytokines
following T cell receptor (TCR) activation and can shape the immune response in many …
following T cell receptor (TCR) activation and can shape the immune response in many …
CD1: antigen presentation and T cell function
M Brigl, MB Brenner - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
patterns of intracellular trafficking of CD1 molecules, and how they sample different …
CD1d–lipid-antigen recognition by the semi-invariant NKT T-cell receptor
NA Borg, KS Wun, L Kjer-Nielsen, MCJ Wilce… - Nature, 2007 - nature.com
The CD1 family is a large cluster of non-polymorphic, major histocompatibility complex
(MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T …
(MHC) class-I-like molecules that bind distinct lipid-based antigens that are recognized by T …
The regulatory role of Vα14 NKT cells in innate and acquired immune response
M Taniguchi, M Harada, S Kojo… - Annual review of …, 2003 - annualreviews.org
A novel lymphocyte lineage, Vα14 natural killer T (NKT) cells, is now well established as
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 …
distinct from conventional αβ T cells. Vα14 NKT cells express a single invariant Vα14 …
The crystal structure of human CD1d with and without α-galactosylceramide
M Koch, VS Stronge, D Shepherd, SD Gadola… - Nature …, 2005 - nature.com
The glycolipid α-galactosylceramide binds with high affinity to CD1d and stimulates natural
killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic α …
killer T cells. Here we report the crystal structure of human CD1d in complex with synthetic α …
Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor
Natural killer T cells express a conserved, semi-invariant αβ T cell receptor that has
specificity for self glycosphingolipids and microbial cell wall α-glycuronosylceramide …
specificity for self glycosphingolipids and microbial cell wall α-glycuronosylceramide …
Cell wall glycosphingolipids of Sphingomonas paucimobilis are CD1d‐specific ligands for NKT cells
V Sriram, W Du, J Gervay‐Hague… - European journal of …, 2005 - Wiley Online Library
The current consensus on characterization of NKT cells is based on their reactivity to the
synthetic glycolipid, α‐galactosylceramide (α‐GalCer) in a CD1d‐dependent manner …
synthetic glycolipid, α‐galactosylceramide (α‐GalCer) in a CD1d‐dependent manner …
The length of lipids bound to human CD1d molecules modulates the affinity of NKT cell TCR and the threshold of NKT cell activation
C McCarthy, D Shepherd, S Fleire… - The Journal of …, 2007 - rupress.org
CD1d-restricted lymphocytes recognize a broad lipid range. However, how CD1d-restricted
lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads …
lymphocytes translate T cell receptor (TCR) recognition of lipids with similar group heads …
CD1d ligands: the good, the bad, and the ugly
RR Brutkiewicz - The Journal of Immunology, 2006 - journals.aai.org
The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting
molecules and is responsible for the selection of NKT cells. A number of ligands that can be …
molecules and is responsible for the selection of NKT cells. A number of ligands that can be …
Intracellular pathways of CD1 antigen presentation
DB Moody, SA Porcelli - Nature Reviews Immunology, 2003 - nature.com
Each of the human CD1 proteins takes a different route through secretory and endocytic
compartments before finally arriving at the cell surface, where these proteins present …
compartments before finally arriving at the cell surface, where these proteins present …