Brain-derived neurotrophic factor (BDNF) promotes neuroprotection and neuroregeneration.
In animal models of Parkinson's disease (PD), BDNF enhances the survival of dopaminergic …

Aim of the review This study aimed to reveal the classical signal pathways and important
potential targets of traditional Chinese medicine (TCM) for treating Alzheimer's disease (AD) …

Abstract Polygalae Radix (Polygalaceae), the dried root of Polygala tenuifolia Willd. and
Polygala sibirica L., has been widely used as a medicine for improving cognitive function. In …

Context Alzheimer's disease (AD) is a chronic neurodegenerative disease that originates
from central nervous system lesions or recessions. Current estimates suggest that this …

Oxidative stress is one of the pathological mechanisms of Alzheimer's disease (AD), and
ferroptosis has been determined to be involved in neurodegenerative diseases such as AD …

Alzheimer's disease (AD) is mainly characterized by the deposition of extracellular amyloid
plaques and intracellular accumulation of neurofibrillary tangles (NFTs). While the recent …

Ethnopharmacological relevance Senegenin (SEN), an active compound extracted from the
traditional Chinese herb Polygala tenuifolia Willd.(a species in the genus Polygala, family …

Radix Polygalae (also known as Yuanzhi in China) is the dried rhizome of Polygala
tenuifolia Willd. or Polygala sibirica L., which is a famous Chinese herb and has been widely …

Background In recent years, sleep problems have emerged as a significant factor in the
development of diseases that influence cognitive function. The inflammatory response may …

Alzheimer's disease (AD) threatens elderly human health and still lacks effective treatment.
Our previous work showed that LGZGD possessed a neuroprotective effect on the Aβ 25–35 …