Food allergies manifest in a variety of clinical conditions within the gastrointestinal tract, skin
and lungs, with the most dramatic and sometimes fatal manifestation being anaphylactic …

Thymic stromal lymphopoietin (TSLP) is a pleiotropic cytokine originally isolated from a
murine thymic stromal cell line. TSLP exerts its biological effects by binding to a high-affinity …

Eosinophils have been traditionally perceived as terminally differentiated cytotoxic effector
cells. Recent studies have profoundly altered this simplistic view of eosinophils and their …

Eosinophilic esophagitis is an increasingly common diagnosis among children evaluated for
feeding problems and among adults with dysphagia and food impaction. This review …

Eosinophilic esophagitis (EoE) is a clinicopathologic condition of increasing recognition and
prevalence. In 2007, a consensus recommendation provided clinical and histopathologic …

Atopic dermatitis often precedes the development of other atopic diseases. The atopic march
describes this temporal relationship in the natural history of atopic diseases. Although the …

The cytokine TSLP has been shown to be a key factor in maintaining immune homeostasis
and regulating inflammatory responses at mucosal barriers. While the role of TSLP in type 2 …

Triticum aestivum (bread wheat) is the most widely grown crop worldwide. In genetically
predisposed individuals, wheat can cause specific immune responses. A food allergy to …

Abstract CD4+ T-helper type 2 (TH2) cells, characterized by their expression of interleukin
(IL)-4, IL-5, IL-9 and IL-13, are required for immunity to helminth parasites and promote the …

Basophils were discovered by Paul Ehrlich in 1879 and represent the least abundant
granulocyte population in mammals. The relative rarity of basophils and their phenotypic …