Congenital anomalies of the kidney and urinary tract (CAKUT) refer to a spectrum of
structural renal malformations and are the leading cause of end-stage renal disease in …

MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate
protein-coding gene expression post-transcriptionally via base pairing between the 5 …

MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression.
They have important roles during kidney development, homeostasis and disease. In …

Autosomal dominant polycystic kidney disease (ADPKD) is caused by germline mutations of
PKD1 or PKD2 on one allele and a somatic mutation inactivating the remaining normal …

Autosomal dominant polycystic kidney disease (ADPKD), among the most common human
genetic conditions and a frequent etiology of kidney failure, is primarily caused by …

Polycystic kidney disease (PKD), the most common genetic cause of chronic kidney failure,
is characterized by the presence of numerous, progressively enlarging fluid-filled cysts in the …

MicroRNAs (miRNAs) belong to a class of endogenous small noncoding RNAs that regulate
gene expression at the posttranscriptional level, through both translational repression and …

MicroRNAs (miRNA) are endogenous short noncoding RNAs, which regulate virtually all
major cellular processes by inhibiting target gene expression. In kidneys, miRNAs have …

Tubular cell necrosis is a key histological feature of acute kidney injury (AKI). Necroptosis is
a type of programed necrosis, which is executed by mixed lineage kinase domain-like …

Polycystic kidney disease (PKD) is a life‐threatening genetic disorder characterized by the
presence of fluid‐filled cysts primarily in the kidneys. PKD can be inherited as autosomal …