Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Myelodysplastic Neoplasms (MDS) are a group of clonal disorders characterized by
ineffective hematopoiesis and morphologic dysplasia. Clinical manifestations of MDS vary …

Mouse models for atopic dermatitis (AD) are an indispensable preclinical research tool for
testing new candidate AD therapeutics and for interrogating AD pathobiology in vivo. In this …

The advent of novel cancer immunotherapy approaches is revolutionizing the treatment for
cancer. Current small animal models for most cancers are syngeneic or genetically …

Cancer “stem cells”(CSCs) sustain the hierarchies of dividing cells that characterize cancer.
The main causes of cancer-related mortality are metastatic disease and relapse, both of …

Preclinical research of myelodysplastic syndromes (MDSs) is hampered by a lack of feasible
disease models. Previously, we have established a robust patient-derived xenograft (PDX) …

We describe the design and synthesis of OFS-1, an Osteoadsorptive Fluorogenic Sentinel
imaging probe that is adsorbed by hydroxyapatite (HAp) and bone mineral surfaces, where it …

Highlights•Humanized 3-D scaffolds improve engraftment of MDS patient samples into NSG
mice.•Human bone marrow niche cells can be maintained long term in xenotransplanted …

Ginseng may improve the myelosuppression and intestinal microbiota disorder induced by
cyclophosphamide (CY); however, the effect of ginseng components on hematopoietic stem …

Highlights•In vivo ossicle models and ex vivo bioreactors are new models used to study
human hematopoiesis and leukemogenesis and the bone marrow microenvironment.• …