The cellular lives of Wolbachia

J Porter, W Sullivan - Nature Reviews Microbiology, 2023 - nature.com
Wolbachia are successful Gram-negative bacterial endosymbionts, globally infecting a large
fraction of arthropod species and filarial nematodes. Efficient vertical transmission, the …

Toward an accurate mechanistic understanding of Wolbachia‐induced cytoplasmic incompatibility

W Wang, W Cui, H Yang - Environmental Microbiology, 2022 - Wiley Online Library
Wolbachia are the most successful intracellular bacteria in arthropods. They can manipulate
host reproduction to favour infected females, which transmit Wolbachia to their progeny and …

Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility

B Horard, K Terretaz, AS Gosselin-Grenet, H Sobry… - Current Biology, 2022 - cell.com
Wolbachia are widespread endosymbiotic bacteria that manipulate the reproduction of
arthropods through a diversity of cellular mechanisms. In cytoplasmic incompatibility (CI), a …

The Cif proteins from Wolbachia prophage WO modify sperm genome integrity to establish cytoplasmic incompatibility

R Kaur, BA Leigh, IT Ritchie, SR Bordenstein - PLoS biology, 2022 - journals.plos.org
Inherited microorganisms can selfishly manipulate host reproduction to drive through
populations. In Drosophila melanogaster, germline expression of the native Wolbachia …

Transgenic expression of cif genes from Wolbachia strain wAlbB recapitulates cytoplasmic incompatibility in Aedes aegypti

CJ McNamara, TH Ant, T Harvey-Samuel… - Nature …, 2024 - nature.com
The endosymbiotic bacteria Wolbachia can invade insect populations by modifying host
reproduction through cytoplasmic incompatibility (CI), an effect that results in embryonic …

Prophage proteins alter long noncoding RNA and DNA of developing sperm to induce a paternal-effect lethality

R Kaur, A McGarry, JD Shropshire, BA Leigh… - Science, 2024 - science.org
The extent to which prophage proteins interact with eukaryotic macromolecules is largely
unknown. In this work, we show that cytoplasmic incompatibility factor A (CifA) and B (CifB) …

Functional analysis of Wolbachia Cid effectors unravels cooperative interactions to target host chromatin during replication

K Terretaz, B Horard, M Weill, B Loppin… - PLoS …, 2023 - journals.plos.org
Wolbachia are common bacteria among terrestrial arthropods. These endosymbionts
transmitted through the female germline manipulate their host reproduction through several …

Genomic underpinnings of Cytoplasmic Incompatibility: CIF gene-neighborhood diversification through extensive lateral transfers and recombination in Wolbachia

Y Tan, L Aravind, D Zhang - Genome Biology and Evolution, 2024 - academic.oup.com
Cytoplasmic incompatibility (CI), a non-Mendelian genetic phenomenon, involves the
manipulation of host reproduction by Wolbachia, a maternally transmitted …

The CinB Nuclease from wNo Wolbachia Is Sufficient for Induction of Cytoplasmic Incompatibility in Drosophila

G Sun, M Zhang, H Chen, M Hochstrasser - MBio, 2022 - Am Soc Microbiol
Wolbachia is an obligate intracellular bacterium that can alter reproduction of its arthropod
hosts, often through a mechanism called cytoplasmic incompatibility (CI). In CI, uninfected …

Crystal Structures of Wolbachia CidA and CidB Reveal Determinants of Bacteria-induced Cytoplasmic Incompatibility and Rescue

H Wang, Y Xiao, X Chen, M Zhang, G Sun… - Nature …, 2022 - nature.com
Cytoplasmic incompatibility (CI) results when Wolbachia bacteria-infected male insects mate
with uninfected females, leading to embryonic lethality.“Rescue” of viability occurs if the …